| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/35-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 62 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ZBTB3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZBTB3抗体的3篇虚构参考文献示例(仅供学术写作参考，非真实文献)：
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1. **文献名称**：*ZBTB3 regulates DNA damage response in cancer cells via p53 pathway*
**作者**：Smith J, et al.
**摘要**：本研究利用ZBTB3特异性抗体进行ChIP-seq分析，发现ZBTB3通过结合p53启动子区域调控DNA损伤修复机制，在乳腺癌细胞中抑制基因组不稳定性。
2. **文献名称**：*Characterization of ZBTB3 antibody specificity in neurodegenerative disease models*
**作者**：Lee H, et al.
**摘要**：通过Western blot和免疫组化验证ZBTB3抗体的特异性，发现ZBTB3在小鼠脑组织中的异常表达与Tau蛋白聚集相关，提示其在阿尔茨海默病中的潜在作用。
3. **文献名称**：*ZBTB3 modulates inflammatory signaling in macrophages*
**作者**：Garcia R, et al.
**摘要**：研究使用ZBTB3抗体进行流式细胞术分析，证实ZBTB3通过抑制NF-κB通路降低巨噬细胞中IL-6和TNF-α的分泌，从而调控炎症反应。
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注：以上内容为模拟生成，实际文献需通过PubMed/Google Scholar等平台检索。如需真实文献，建议补充实验物种或具体研究领域以缩小范围。
The ZBTB3 antibody is a tool used to detect ZBTB3 (Zinc Finger and BTB Domain-Containing Protein 3), a member of the ZBTB family of transcription factors characterized by zinc finger motifs and a BTB (Broad-Complex, Tramtrack, Bric-à-brac) domain. ZBTB3 is implicated in transcriptional regulation, chromatin remodeling, and cellular processes such as differentiation, proliferation, and apoptosis. Its precise biological functions remain under investigation, but studies suggest potential roles in cancer biology, immune regulation, and developmental pathways. Dysregulation of ZBTB3 has been linked to tumorigenesis in certain cancers, acting as either an oncogene or tumor suppressor depending on the cellular context.
ZBTB3 antibodies are typically monoclonal or polyclonal, generated by immunizing animals (e.g., rabbits or mice) with recombinant ZBTB3 protein fragments. These antibodies are validated for applications like Western blotting, immunofluorescence, immunohistochemistry, and chromatin immunoprecipitation (ChIP). Specificity is confirmed via knockout cell lines or siRNA-mediated knockdown. Researchers use ZBTB3 antibodies to explore its expression patterns, interactions with DNA or proteins, and involvement in signaling pathways. Commercial availability from multiple suppliers facilitates its study, though validation in specific experimental systems is critical due to potential cross-reactivity. Understanding ZBTB3's role may contribute to insights into disease mechanisms and therapeutic targeting.
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