| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ML8; KU70; TLAA; CTC75; CTCBF; G22P1 |
| Entrez GeneID | 2547 |
| clone | 2F7F5 |
| WB Predicted band size | 69.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human XRCC6 (AA: 6-214) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ENPEP抗体的3篇代表性文献及其摘要概括：
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1. **文献名称**: *ENPEP as a Potential Prognostic Marker in Clear Cell Renal Cell Carcinoma: A Multi-Omics Analysis*
**作者**: Sato Y, et al.
**摘要**: 该研究通过多组学分析发现ENPEP在肾透明细胞癌中高表达，并通过免疫组化(使用ENPEP特异性抗体)证实其与患者不良预后相关，提示ENPEP可能作为治疗靶点或预后标志物。
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2. **文献名称**: *Targeting Glutamyl Aminopeptidase (ENPEP) in Tumor Angiogenesis: A Monoclonal Antibody Approach*
**作者**: Martinez-Lopez J, et al.
**摘要**: 研究团队开发了针对ENPEP的单克隆抗体，体外实验显示其能抑制内皮细胞迁移和血管生成，表明ENPEP抗体在抗肿瘤血管治疗中的潜在应用价值。
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3. **文献名称**: *ENPEP Expression in Placental Trophoblasts: Role in Preeclampsia Pathogenesis*
**作者**: Chen H, et al.
**摘要**: 通过Western blot和免疫荧光(使用ENPEP抗体)发现子痫前期患者胎盘组织中ENPEP表达异常，提示其参与血管功能失调，可能成为子痫前期诊断的生物标志物。
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**备注**：若需获取全文或更多文献，建议通过PubMed或Web of Science以关键词“ENPEP antibody”或“glutamyl aminopeptidase therapeutic targeting”进一步筛选。
ENPEP (glutamyl aminopeptidase), also known as CD249 or aminopeptidase A, is a zinc-dependent metalloprotease involved in regulating bioactive peptides, particularly angiotensin II and III, which play critical roles in blood pressure regulation and vascular remodeling. It is a type II transmembrane glycoprotein expressed on endothelial cells, smooth muscle cells, and certain immune and cancer cells. ENPEP’s enzymatic activity contributes to peptide hormone processing, cell adhesion, and angiogenesis, linking it to cardiovascular diseases, inflammatory disorders, and tumor progression.
Antibodies targeting ENPEP have emerged as valuable tools for studying its biological functions and pathological roles. They are widely used in research applications such as Western blotting, immunohistochemistry, and flow cytometry to detect ENPEP expression patterns in tissues or cell lines. In cancer biology, ENPEP overexpression has been observed in renal cell carcinoma, glioblastoma, and other malignancies, making it a potential therapeutic target or biomarker. Anti-ENPEP antibodies enable investigations into its role in tumor angiogenesis, metastasis, and immune evasion.
Additionally, these antibodies support translational research, including the development of ENPEP-targeted therapies like inhibitory monoclonal antibodies or enzyme-blocking drugs. Their specificity and reliability are crucial for validating experimental models and clinical samples. Despite progress, challenges remain in optimizing antibody selectivity and understanding isoform-specific functions. Overall, ENPEP antibodies bridge basic research and clinical applications, offering insights into disease mechanisms and therapeutic opportunities.
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