| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | BTBD20; KBTBD14 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CCIN |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CCIN抗体的3篇参考文献示例，基于假设性研究场景整理：
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1. **文献名称**：*Calicin: A Novel Sperm-Specific Protein Involved in Nuclear Morphogenesis*
**作者**：Smith, J. et al.
**摘要**：该研究利用抗Calicin(CCIN)抗体揭示了其在哺乳动物精子顶体后区的定位，证实其通过调控细胞骨架参与精子头部核成熟，缺失导致不育。
2. **文献名称**：*Characterization of CCIN Antibody for Detecting Centrosome Abnormalities in Cancer*
**作者**：Zhang, L. et al.
**摘要**：团队开发了高特异性CCIN单克隆抗体，用于免疫组化检测乳腺癌样本中的中心体异常，发现CCIN表达下调与基因组不稳定性及预后不良相关。
3. **文献名称**：*CCIN Knockdown Disrupts Oocyte Meiosis via Antibody-Mediated Protein Blockade*
**作者**：Garcia, R. et al.
**摘要**：通过显微注射CCIN抗体阻断小鼠卵母细胞中的蛋白功能，发现CCIN在减数分裂纺锤体组装中起关键作用，其缺失导致染色体分离错误。
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注：以上文献为模拟示例，实际研究中请通过PubMed或Google Scholar以关键词“CCIN antibody”或“Calicin antibody”检索最新文献。若CCIN指代其他蛋白(如研究团队自定缩写)，建议结合具体研究背景细化检索策略。
CCIN antibody, targeting the CCIN (Cajal body component) protein, is a research tool primarily used to study nuclear suborganelles called Cajal bodies (CBs). Discovered in the early 20th century, CBs are dynamic structures involved in RNA processing, particularly the biogenesis of small nuclear ribonucleoproteins (snRNPs) and telomerase assembly. The CCIN protein, also known as coilin, serves as a scaffold for CB formation and recruitment of factors like SMN complex components.
CCIN antibodies are widely employed in immunofluorescence, Western blotting, and immunoprecipitation to investigate CB dynamics during the cell cycle, stress responses, and diseases. Studies using these antibodies have revealed CB disassembly in mitosis, their role in viral infections, and associations with neurological disorders (e.g., spinal muscular atrophy) and cancers. Recent research also explores CCIN's involvement in DNA repair mechanisms. However, CBs remain partially enigmatic, and CCIN antibodies continue to be crucial for deciphering their molecular functions. Commercial CCIN antibodies are typically raised against conserved regions (e.g., human coilin amino acids 1-300) and validated across species, though functional variations between isoforms require careful experimental design.
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