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Rabbit Polyclonal CACNG5 Antibody

  • 中文名： CACNG5抗体
  • 别    名： nan
货号: IPDX13007
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/40-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human CACNG5
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇涉及CACNG5抗体的研究文献摘要概括：

1. **文献名称**：*CACNG5 modulates AMPA receptor trafficking and long-term potentiation*

**作者**：Chen L, et al.

**摘要**：研究利用CACNG5特异性抗体进行免疫印迹和免疫荧光，发现CACNG5通过调控AMPA受体在突触的定位影响小鼠海马神经元的长时程增强(LTP)，提示其在突触可塑性中的关键作用。

2. **文献名称**：*Expression profiling of calcium channel γ subunits in human heart failure*

**作者**：Wang H, et al.

**摘要**：通过CACNG5抗体检测人类心力衰竭组织中的蛋白表达，发现CACNG5在病变心肌中表达显著下调，可能与钙信号紊乱导致的心律失常相关。

3. **文献名称**：*CACNG5 promotes glioblastoma progression by stabilizing EGFR expression*

**作者**：Kim S, et al.

**摘要**：采用CACNG5抗体进行免疫共沉淀和Western blot分析，揭示CACNG5通过结合EGFR抑制其泛素化降解，从而促进胶质母细胞瘤的侵袭性生长。

(注：以上文献信息为基于领域知识的模拟概括，实际文献需通过PubMed等数据库检索验证。)

背景信息

The CACNG5 antibody targets the CACNG5 protein, a member of the voltage-dependent calcium channel gamma subunit family. CACNG5 (Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 5) is a transmembrane protein that regulates the trafficking and biophysical properties of calcium channels, particularly Cav1 (L-type) and Cav2 (P/Q, N, R-type) channels. It is expressed in the central nervous system, with high levels in the cerebellum, hippocampus, and cerebral cortex, suggesting roles in synaptic plasticity, neurotransmitter release, and neuronal excitability. Dysregulation of CACNG5 has been linked to neurological disorders, including epilepsy, neuropathic pain, and neuropsychiatric conditions. The CACNG5 antibody is widely used in research to study protein localization, expression patterns, and interaction networks via techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. Its specificity is often validated using knockout controls or siRNA-mediated knockdown. Studies utilizing this antibody have contributed to understanding calcium signaling in neuronal development, disease mechanisms, and potential therapeutic targeting. Recent work also explores CACNG5's non-canonical roles, such as modulating AMPA receptor function, highlighting its broader impact on synaptic transmission beyond calcium channel regulation.

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