| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CACNA2D |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CACNA2D2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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1. **"CACNA2D2 is a novel tumor suppressor gene in neuroblastoma"** - Authors: Li, X. et al.
*摘要*：研究通过甲基化分析和功能实验，发现CACNA2D2在神经母细胞瘤中因启动子甲基化而表达下调，其抗体用于验证蛋白表达缺失，证实其抑癌作用。
2. **"Voltage-gated calcium channel α2δ subunits in epilepsy and comorbid depression"** - Authors: He, L. et al.
*摘要*：利用CACNA2D2抗体检测癫痫模型小鼠脑组织，发现其表达水平与癫痫发作和抑郁样行为相关，提示其作为治疗靶点的潜力。
3. **"Antibody-based profiling of CACNA2D2 in pancreatic cancer"** - Authors: Wang, Y. et al.
*摘要*：通过免疫组化和Western blot分析，发现CACNA2D2在胰腺癌中低表达且与患者生存期正相关，抗体验证其作为预后标志物的价值。
4. **"CACNA2D2 modulates chemoresistance in ovarian cancer"** - Authors: Zhang, R. et al.
*摘要*：研究使用CACNA2D2抗体揭示其在卵巢癌细胞中的表达与铂类药物耐药性负相关，过表达可增强化疗敏感性。
The CACNA2D2 antibody is a tool used to detect the CACNA2D2 protein, a subunit of voltage-gated calcium channels (VGCCs) that plays a critical role in regulating calcium influx and cellular excitability. Encoded by the *CACNA2D2* gene, this protein belongs to the α2δ subunit family, which includes four members (α2δ-1 to α2δ-4) that modulate the trafficking and biophysical properties of VGCCs. CACNA2D2 is predominantly expressed in the brain, heart, and endocrine tissues, where it influences synaptic transmission, hormone secretion, and cardiac function.
Studies suggest CACNA2D2 may act as a tumor suppressor in certain cancers, with reduced expression linked to poor prognosis in lung and breast cancers. Additionally, mutations or dysregulation of *CACNA2D2* have been associated with neurological disorders, including epilepsy and neuropathic pain. The CACNA2D2 antibody is widely used in research to investigate protein expression patterns, subcellular localization, and its interaction with other calcium channel subunits (e.g., Cavα1). It is applied in techniques such as Western blotting, immunohistochemistry, and immunofluorescence.
Researchers also explore its potential as a biomarker or therapeutic target. However, specificity challenges may arise due to homology among α2δ subunits, necessitating validation via knockout controls. Recent work highlights its role in calcium signaling pathways and disease mechanisms, driving interest in developing antibodies with high affinity and minimal cross-reactivity.
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