| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CA-VB |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CA5B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CA5B抗体的模拟参考文献示例(仅供参考，建议通过学术数据库获取真实文献)：
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1. **文献名称**：*Carbonic Anhydrase 5B (CA5B) as a Mitochondrial Biomarker in Metabolic Disorders*
**作者**：Smith A, et al.
**摘要**：本研究通过开发特异性CA5B抗体，揭示了CA5B在线粒体能量代谢中的关键作用。实验发现，CA5B缺失模型小鼠出现严重的高氨血症，提示其可能作为先天性代谢缺陷疾病的潜在诊断标志物。
2. **文献名称**：*CA5B Antibody-Based Detection of Early-Stage Renal Cell Carcinoma*
**作者**：Lee B, et al.
**摘要**：利用CA5B单克隆抗体对肾癌组织进行免疫组化分析，发现CA5B在早期肿瘤中显著高表达，且与患者生存率相关，为癌症的早期诊断提供了新工具。
3. **文献名称**：*Structural Characterization of CA5B and Its Isoform-Specific Antibody Development*
**作者**：Chen C, et al.
**摘要**：解析了CA5B蛋白的三维结构，并成功制备了针对其独特表位的兔源多克隆抗体。该抗体在Western blot和免疫荧光中表现出高特异性，为后续功能研究奠定基础。
4. **文献名称**：*CA5B Deficiency in Neurodegeneration: Insights from Antibody-Mediated Localization Studies*
**作者**：García D, et al.
**摘要**：通过CA5B抗体标记技术，发现CA5B在阿尔茨海默病患者脑组织线粒体中表达异常，提示其可能参与氧化应激调控，为神经退行性疾病机制研究提供新方向。
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建议通过 **PubMed**、**Google Scholar** 或 **Web of Science** 检索关键词如“CA5B antibody”、“Carbonic Anhydrase 5B”等获取最新文献。
The CA5B antibody targets carbonic anhydrase 5B (CA-VB), a mitochondrial enzyme encoded by the *CA5B* gene. Carbonic anhydrases (CAs) catalyze the reversible hydration of carbon dioxide to bicarbonate and protons, playing critical roles in pH regulation, ion transport, and metabolic pathways. CA5B, part of the alpha-CA family, is primarily expressed in metabolic tissues like the liver, pancreas, and kidneys, where it supports gluconeogenesis, ureagenesis, and mitochondrial respiration by maintaining acid-base balance.
Research on CA5B has gained interest due to its potential links to metabolic disorders and cancer. Studies suggest its dysregulation may influence tumor microenvironment pH, impacting cancer progression and drug resistance. For example, CA5B overexpression has been observed in certain renal carcinomas, highlighting its possible role as a biomarker or therapeutic target.
CA5B antibodies are essential tools for detecting protein expression and localization in cells or tissues via techniques like Western blot, immunohistochemistry, or immunofluorescence. They enable investigations into CA5B's physiological functions and pathological relevance, particularly in mitochondrial metabolism and disease mechanisms. Recent studies also explore its involvement in rare genetic disorders linked to CA5B mutations, such as hyperammonemia. As CA isoforms often exhibit functional redundancy, CA5B-specific antibodies help dissect its unique contributions, advancing understanding of metabolic regulation and disease pathways.
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