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Rabbit Polyclonal HGH1 Antibody

  • 中文名: HGH1抗体
  • 别    名: BRP16; BRP16L; FAM203A; FAM203B; C8orf30A; C8orf30B
货号: IPDX12997
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/30-1/150 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesBRP16; BRP16L; FAM203A; FAM203B; C8orf30A; C8orf30B
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human HGH1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇关于HGH1(人类生长激素1)抗体的模拟参考文献示例(非真实文献,仅供格式参考):

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1. **文献名称**:*Development and Validation of a High-Sensitivity HGH1 Antibody for Diagnostic Applications*

**作者**:Smith J, et al.

**摘要**:研究团队开发了一种高灵敏度的单克隆HGH1抗体,通过噬菌体展示技术筛选,验证其在血清HGH1水平检测中的特异性,可用于垂体功能异常的临床诊断。

2. **文献名称**:*HGH1 Autoantibodies in Growth Hormone Deficiency: Clinical Implications*

**作者**:Chen L, et al.

**摘要**:探讨了HGH1自身抗体在生长激素缺乏症患者中的存在及其对激素替代治疗的干扰,提出抗体滴度监测可优化治疗方案。

3. **文献名称**:*Structural Characterization of HGH1 Antibody Epitopes Using Cryo-EM*

**作者**:Gupta R, et al.

**摘要**:利用冷冻电镜技术解析HGH1抗体与靶标蛋白的结合位点,揭示了抗体-抗原相互作用的分子机制,为治疗性抗体设计提供结构基础。

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*注:以上文献为示例,实际引用需查询PubMed、Google Scholar等数据库获取真实研究。*

背景信息

Human growth hormone 1 (HGH1), also known as somatotropin, is a peptide hormone essential for growth regulation, metabolism, and cell repair. Produced by the anterior pituitary gland, HGH1 stimulates tissue growth via insulin-like growth factor 1 (IGF-1) and influences lipid, carbohydrate, and protein metabolism. Antibodies targeting HGH1 are critical tools in research, diagnostics, and therapeutics. In research, they enable the detection and quantification of HGH1 in biological samples using techniques like ELISA, Western blotting, and immunohistochemistry, aiding studies on growth disorders, pituitary function, and hormone-related pathologies. Clinically, HGH1 antibodies are employed in diagnostic kits to assess growth hormone deficiency or excess (e.g., gigantism, acromegaly). Therapeutic applications include the development of anti-HGH1 biologics to neutralize excessive hormone activity in conditions like acromegaly or certain cancers. However, challenges persist, such as ensuring antibody specificity to avoid cross-reactivity with structurally similar hormones (e.g., placental GH) and optimizing pharmacokinetics for clinical use. Advances in recombinant antibody engineering and epitope mapping continue to refine HGH1 antibody efficacy, supporting personalized medicine approaches and deeper insights into growth hormone signaling pathways.

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