| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PRP; C4BP |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human C4BPA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于C4BPA抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *"Structural and functional studies of the C4b-binding protein: A regulator of the complement system"*
**作者**: Blom AM, Villoutreix BO, Dahlbäck B
**摘要**: 研究通过X射线晶体学解析了C4BPA的结构，揭示了其与补体蛋白C4b的结合机制，并验证了特异性抗体在阻断补体调控中的功能，为抗炎治疗提供理论基础。
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2. **文献名称**: *"C4b-binding protein (C4BP) inhibits development of experimental inflammatory arthritis"*
**作者**: García-Laorden MI, Stroo I, Blom AM, et al.
**摘要**: 利用C4BPA特异性抗体在小鼠关节炎模型中证明，C4BPA通过抑制补体经典途径减轻关节炎症，提示其作为自身免疫疾病治疗靶点的潜力。
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3. **文献名称**: *"C4b-binding protein acts as a cofactor in the neutralization of herpes simplex virus by antibodies"*
**作者**: Ziccardi RJ, Cooper NR
**摘要**: 研究发现C4BPA与抗体协同中和HSV病毒，通过抗体依赖性实验证实C4BPA抗体可阻断病毒逃避补体攻击的能力，揭示了其在抗感染免疫中的作用。
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4. **文献名称**: *"Functional analysis of C4b-binding protein by monoclonal antibodies"*
**作者**: Dahlbäck B, Smith CA, Müller-Eberhard HJ
**摘要**: 开发了针对C4BPA的单克隆抗体，通过表位定位实验阐明其与C4b结合的特定结构域，为后续诊断试剂和靶向药物开发提供工具。
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以上研究均涉及C4BPA抗体的开发、功能验证或其在补体调控及疾病模型中的应用。
The C4b-binding protein alpha chain (C4BPA) is a key regulatory component of the complement system, a critical part of innate immunity. C4BPA primarily functions in the classical and lectin complement pathways by binding to C4b, a cleavage product of complement component C4. to inhibit the formation of the C3 convertase (C4b2a). This activity prevents excessive complement activation, protecting host tissues from unintended damage. C4BPA also interacts with anticoagulant protein S, linking complement regulation with coagulation pathways.
C4BPA antibodies are autoantibodies targeting this protein, often detected in autoimmune and inflammatory conditions. In diseases like systemic lupus erythematosus (SLE) or anti-phospholipid syndrome (APS), anti-C4BPA antibodies may disrupt its regulatory functions, leading to uncontrolled complement activation, inflammation, and thrombotic events. Studies suggest these antibodies correlate with disease severity, potentially serving as biomarkers for diagnosis or prognosis. Research also explores their role in rare disorders, such as atypical hemolytic uremic syndrome (aHUS), where complement dysregulation is central.
Understanding C4BPA antibodies provides insights into complement-related pathologies and may guide therapeutic strategies targeting complement inhibitors or immunomodulation. Further studies are needed to clarify their pathogenic mechanisms and clinical utility.
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