| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | KU80; KUB2; Ku86; NFIV; KARP1; KARP-1; FLJ39089 |
| Entrez GeneID | 7520 |
| clone | 5C5 |
| WB Predicted band size | 86kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Purified recombinant fragment of human XRCC5 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CALML6抗体的3篇参考文献示例(注：文献信息为虚构，仅供示例参考)：
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1. **标题**: *CALML6 as a Novel Biomarker in Breast Cancer: Immunohistochemical Analysis*
**作者**: Zhang Y, et al.
**摘要**: 本研究通过免疫组化(使用CALML6特异性抗体)检测CALML6在乳腺癌组织中的表达，发现其高表达与肿瘤分级和不良预后显著相关，提示其作为潜在治疗靶点的可能性。
2. **标题**: *Functional Characterization of CALML6 in Cutaneous Squamous Cell Carcinoma Using Antibody-Based Knockdown*
**作者**: Lee S, et al.
**摘要**: 通过siRNA和CALML6抗体验证，研究发现CALML6通过调控钙信号通路促进皮肤鳞癌细胞迁移，抗体用于Western blot和免疫荧光证实蛋白表达下调。
3. **标题**: *CALML6 Expression Correlates with Bladder Cancer Progression: A Tissue Microarray Study*
**作者**: Gupta R, et al.
**摘要**: 利用CALML6抗体对膀胱癌组织芯片进行染色，分析显示CALML6高表达与肿瘤侵袭性和转移相关，可能作为分期辅助标志物。
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*注：以上文献为模拟示例，实际研究中请通过PubMed或专业数据库检索具体文献。*
The CALML6 antibody is designed to detect CALML6 (Calmodulin-Like Protein 6), a member of the calmodulin family involved in calcium-mediated signaling pathways. CALML6. encoded by the *CALML6* gene on human chromosome 1p36.13. shares structural homology with calmodulin, containing EF-hand calcium-binding domains critical for interacting with target proteins. Unlike ubiquitously expressed calmodulin, CALML6 exhibits tissue-specific expression, notably in the skin, prostate, and kidney, suggesting specialized roles in these tissues. Studies indicate its involvement in regulating epidermal differentiation, cell proliferation, and apoptosis, with potential implications in skin disorders or cancers.
CALML6 antibodies are primarily used in research to investigate its expression patterns, subcellular localization, and molecular interactions. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the exploration of CALML6's functional roles. For instance, studies using these antibodies have linked CALML6 overexpression to tumor suppression in certain cancers, while reduced levels correlate with poor differentiation in skin squamous cell carcinoma. However, its precise mechanisms remain under investigation, partly due to functional redundancy within the calmodulin family. Researchers rely on CALML6-specific antibodies to dissect its unique contributions to calcium signaling and disease pathways, making it a valuable tool in cellular and molecular biology.
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