| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CORONIN-2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CORO1B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CORO1B抗体的3篇模拟参考文献示例(实际文献需通过学术数据库查询)：
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1. **文献名称**：*Coronin 1B regulates cell migration through actin cytoskeleton remodeling in breast cancer cells*
**作者**：Zhang Y, et al.
**摘要**：本研究揭示CORO1B通过调控肌动蛋白细胞骨架重组促进乳腺癌细胞迁移。实验表明，CORO1B抗体通过抑制其与Arp2/3复合物的相互作用，显著降低癌细胞的侵袭能力，提示其作为潜在治疗靶点。
2. **文献名称**：*CORO1B modulates macrophage phagocytosis and inflammatory response via TLR4 signaling*
**作者**：Chen L, et al.
**摘要**：文章利用CORO1B抗体进行免疫共沉淀和功能实验，发现CORO1B通过TLR4通路调控巨噬细胞的吞噬功能及炎症因子释放，为免疫相关疾病机制提供新见解。
3. **文献名称**：*Structural insights into CORO1B-antibody interaction and its application in glioblastoma diagnosis*
**作者**：Wang X, et al.
**摘要**：该研究解析了CORO1B蛋白与其特异性抗体的结合表位，并开发了一种基于CORO1B抗体的免疫组化检测方法，证明其在胶质母细胞瘤组织中的高表达与患者预后相关。
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**备注**：以上为模拟示例，真实文献建议通过PubMed、Google Scholar或Web of Science检索关键词“CORO1B antibody”“CORO1B function”等获取。
The CORO1B antibody is a crucial tool for studying coronin-1B (CORO1B), a member of the coronin protein family involved in regulating actin cytoskeleton dynamics. Coronins are evolutionarily conserved proteins that play roles in cell migration, membrane trafficking, and immune responses. CORO1B, specifically, is ubiquitously expressed and interacts with actin filaments and Arp2/3 complexes to modulate actin polymerization, branching, and network remodeling. It also participates in signaling pathways linked to cell motility, vesicle trafficking, and phagocytosis. Dysregulation of CORO1B has been associated with cancer metastasis, neurological disorders, and immune dysfunctions, making it a target for biomedical research.
The CORO1B antibody enables detection and quantification of CORO1B protein levels in various experimental setups, including Western blotting, immunofluorescence, and immunohistochemistry. Researchers use it to investigate CORO1B's subcellular localization, interaction partners, and expression patterns under physiological or pathological conditions. Its specificity and reliability are critical for elucidating CORO1B's role in diseases like glioblastoma, breast cancer, and autoimmune disorders. Commercially available CORO1B antibodies are typically raised in hosts like rabbits or mice, with validation across multiple applications. Ongoing studies leveraging this antibody continue to uncover CORO1B's mechanistic contributions to cellular processes, offering potential therapeutic insights.
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