| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CLIPINC |
| WB Predicted band size | 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CORO2B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及CORO2B抗体的文献概览(基于公开数据模拟，非真实文献)：
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1. **文献名称**：Coronin 2B regulates T cell migration via actin cytoskeleton remodeling
**作者**：Li X, et al.
**摘要**：研究利用CORO2B特异性抗体揭示其在T细胞迁移中的作用，发现CORO2B通过调控F-actin动态重组影响免疫细胞趋化性，可能成为炎症疾病治疗靶点。
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2. **文献名称**：CORO2B expression in neuronal development: Insights from knockout mouse models
**作者**：Sato K, et al.
**摘要**：通过CORO2B抗体免疫组化分析，发现CORO2B在小鼠大脑皮层发育中调控神经元突触形成，其缺失导致突触连接异常，提示其在神经发育中的关键作用。
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3. **文献名称**：A novel role of CORO2B in tumor-associated macrophage polarization
**作者**：Wang Y, et al.
**摘要**：使用CORO2B抗体进行流式细胞术和Western blot实验，证实CORO2B通过调控STAT3信号通路促进肿瘤微环境中巨噬细胞向M2型极化，影响肿瘤免疫逃逸。
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如需真实文献，建议通过PubMed或Google Scholar搜索关键词“CORO2B antibody”或“Coronin 2B function”获取近期研究。
The CORO2B antibody targets coronin-2B (also known as Coronin-1C or Clipin-C), a member of the coronin protein family involved in regulating actin cytoskeleton dynamics. Coronins are evolutionarily conserved proteins that modulate cell motility, membrane trafficking, and immune responses by interacting with actin filaments and associated proteins. CORO2B is widely expressed in mammalian tissues, particularly in the brain, immune cells, and epithelial tissues. It contains a conserved coronin core domain with WD40 repeats, enabling interactions with Arp2/3 complex components and other cytoskeletal regulators.
CORO2B plays a role in cell migration, phagocytosis, and intracellular signaling pathways. Studies link it to neuronal development, cancer metastasis, and immune cell function, where its dysregulation may influence pathological processes. Antibodies against CORO2B are essential tools for detecting its expression, localization, and functional roles in these contexts. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to explore CORO2B's involvement in diseases such as neurodevelopmental disorders, autoimmune conditions, and malignancies.
Research utilizing CORO2B antibodies has also shed light on its interaction with autophagy-related proteins and its potential as a biomarker or therapeutic target. However, specificity validation remains critical due to structural similarities among coronin family members. Overall, CORO2B antibodies are pivotal in advancing understanding of cytoskeletal regulation and its implications in health and disease.
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