| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | COX6AH; COXVIAH |
| WB Predicted band size | 11 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human COX6A2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于COX6A2抗体的模拟参考文献示例(实际文献需通过学术数据库查询)：
1. **文献名称**：《Cytochrome c oxidase subunit 6A2 (COX6A2)在心肌缺血中的表达及抗体应用》
**作者**：Smith A, et al.
**摘要**：本研究利用COX6A2特异性抗体，发现其在心肌缺血模型中表达显著下调，提示其可能参与线粒体功能障碍调控。
2. **文献名称**：《COX6A2抗体在肺癌组织中的免疫组化检测分析》
**作者**：Zhang L, et al.
**摘要**：通过开发高特异性COX6A2多克隆抗体，证实其在肺癌组织中异常高表达，可能与肿瘤细胞代谢重编程相关。
3. **文献名称**：《线粒体COX6A2亚基的抗体筛选及其功能研究》
**作者**：Tanaka K, et al.
**摘要**：报道了一种新型单克隆抗体的制备方法，并利用该抗体揭示了COX6A2在神经退行性疾病模型中的定位变化。
4. **文献名称**：《COX6A2作为代谢综合征潜在生物标志物的验证》
**作者**：Garcia R, et al.
**摘要**：通过ELISA和Western blot结合COX6A2抗体，发现其在代谢综合征患者血清中水平异常，提示其临床诊断价值。
**注意**：以上内容为模拟案例，实际文献请通过PubMed、Web of Science或Google Scholar等平台检索关键词“COX6A2 antibody”或“COX6A2 + 研究领域”获取。
The cytochrome c oxidase subunit 6A2 (COX6A2) is a nuclear-encoded subunit of cytochrome c oxidase (COX), also known as Complex IV, the terminal enzyme in the mitochondrial electron transport chain. COX6A2 is specifically expressed in skeletal and cardiac muscle tissues, reflecting its role in energy metabolism and oxidative phosphorylation. This subunit is critical for maintaining the structural integrity and catalytic activity of COX, which facilitates the transfer of electrons to oxygen, driving ATP synthesis.
Antibodies targeting COX6A2 are essential tools for studying its expression, localization, and function in muscle physiology and disease. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in normal versus pathological tissues. Research has linked COX6A2 dysregulation to mitochondrial disorders, myopathies, and metabolic syndromes, making these antibodies valuable for exploring disease mechanisms.
COX6A2 antibodies are typically raised in animal models (e.g., rabbits, mice) using immunogenic peptides or recombinant proteins. Validation includes specificity checks via knockout controls and cross-reactivity assessments. Commercial availability supports research in fields like exercise physiology, cardiomyopathy, and neurodegenerative diseases, where mitochondrial dysfunction is implicated. Understanding COX6A2's role through antibody-based assays continues to advance insights into cellular energy regulation and muscle-specific pathologies.
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