| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DIF2; IEX1; PRG1; DIF-2; GLY96; IEX-1; IEX-1L |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human IER3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IER3抗体的3篇示例参考文献(内容为虚构示例，仅供参考)：
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1. **文献名称**: *IER3 Expression in Gastric Cancer: Prognostic Implications*
**作者**: Zhang Y, et al.
**摘要**: 本研究通过免疫组化分析胃癌组织中IER3蛋白的表达水平，发现IER3高表达与患者生存率降低显著相关。研究使用兔源多克隆IER3抗体(Abcam, ab12345)验证了其在肿瘤微环境中的定位。
2. **文献名称**: *Mechanistic Role of IER3 in Apoptosis Regulation via NF-κB Signaling*
**作者**: Smith JL, et al.
**摘要**: 文章利用Western blot和免疫荧光技术(小鼠单克隆IER3抗体，货号sc-5678)，证实IER3通过调控NF-κB通路影响HEK293细胞的凋亡过程，为癌症治疗提供潜在靶点。
3. **文献名称**: *Development and Validation of a Novel Polyclonal Antibody for IER3 Detection*
**作者**: Lee S, et al.
**摘要**: 本研究报道了一种高特异性的兔抗人IER3多克隆抗体的制备，通过ELISA、Western blot和免疫组化验证其灵敏度及适用性，适用于多种疾病模型的蛋白检测。
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如需实际文献，建议通过PubMed或Google Scholar搜索关键词“IER3 antibody”或“IER3 protein detection”，并筛选近年高引论文。
The Immediate Early Response 3 (IER3) protein, also known as IEX-1. is a stress-inducible regulatory factor encoded by the IER3 gene. It plays critical roles in cell proliferation, apoptosis, and adaptive responses to cellular stress. IER3 interacts with key signaling pathways, including the PI3K/AKT and MAPK cascades, and modulates NF-κB activity, influencing inflammation, immunity, and cancer progression. Its expression is tightly regulated by growth factors, cytokines, DNA damage, and chemotherapeutic agents, reflecting its dual pro-survival or pro-apoptotic functions depending on cellular context.
IER3 antibodies are essential tools for studying its expression, localization, and interactions in various diseases. In cancer research, IER3 antibodies help assess its dysregulation in tumors, such as breast, colorectal, and hepatocellular carcinomas, where it may act as an oncogene or tumor suppressor. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence to explore IER3’s role in chemotherapy resistance, immune evasion, or metastasis.
Recent studies highlight IER3’s potential as a biomarker for disease prognosis or therapeutic targeting. For example, elevated IER3 levels correlate with poor outcomes in certain cancers, while its downregulation links to autoimmune disorders. Commercial IER3 antibodies are typically validated for specificity across human and mouse models, aiding translational research. However, variable post-translational modifications and tissue-specific isoforms necessitate careful antibody selection to ensure experimental accuracy.
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