WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 咨询技术 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
Aliases | CREG |
WB Predicted band size | 24 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse |
Immunogen | Synthetic peptide of human CREG1 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于CREG1抗体的3篇假想参考文献示例(仅供格式参考,非真实文献):
1. **文献名称**: *"CREG1 Antibody Inhibits Tumor Angiogenesis by Targeting Endothelial Cell Proliferation"*
**作者**: Smith JL, et al.
**摘要**: 研究利用CREG1特异性抗体,证实其通过阻断内皮细胞增殖信号通路抑制肿瘤血管生成,减缓小鼠模型中乳腺癌的生长。
2. **文献名称**: *"Monoclonal Anti-CREG1 Antibody Attenuates Cardiac Fibrosis in Hypertensive Rats"*
**作者**: Chen R, et al.
**摘要**: 开发了一种高亲和力抗CREG1单克隆抗体,实验表明其可通过调节TGF-β信号通路减少高血压模型中的心肌纤维化。
3. **文献名称**: *"CREG1-Specific Antibody Reveals Its Role in Maintaining Pluripotency of Embryonic Stem Cells"*
**作者**: Kim S, et al.
**摘要**: 通过免疫沉淀和功能实验,发现CREG1抗体可干扰其与转录因子的相互作用,导致胚胎干细胞多能性丧失。
4. **文献名称**: *"CREG1 Neutralizing Antibody as a Potential Therapeutic for Diabetic Retinopathy"*
**作者**: Patel M, et al.
**摘要**: 研究证明抗CREG1抗体能减少视网膜血管渗漏,通过抑制VEGF过度表达改善糖尿病小鼠的视网膜病变。
(注:以上文献为模拟内容,实际引用需查询真实数据库如PubMed。)
CREG1 (Cellular Repressor of E1A-stimulated Genes 1) is a secreted glycoprotein involved in regulating cellular differentiation, proliferation, and apoptosis. It interacts with the mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) and modulates lysosomal function and extracellular matrix remodeling. Dysregulation of CREG1 has been linked to cancer, cardiovascular diseases, and metabolic disorders, highlighting its role in maintaining cellular homeostasis.
CREG1 antibodies are immunological tools developed to detect and quantify CREG1 protein expression in research and diagnostic applications. These antibodies are typically generated using recombinant CREG1 protein or specific peptide epitopes, enabling their use in techniques like Western blotting, immunohistochemistry (IHC), and ELISA. They help investigate CREG1's tissue distribution, subcellular localization, and interaction partners. In cancer studies, CREG1 antibodies have been employed to explore its dual role as a tumor suppressor or promoter, depending on context. Cardiovascular research utilizes these antibodies to study CREG1's involvement in vascular remodeling and cardiac repair. Validation of CREG1 antibodies includes testing for specificity via knockout controls or siRNA-mediated knockdown. Commercial availability from multiple suppliers has facilitated its adoption in studying lysosomal disorders, aging-related pathologies, and regenerative processes.
×