| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HK5; Kallikrein 5; Kallikrein L2; KLK 5; KLK L2; SCTE;;Kallikrein 5 |
| WB Predicted band size | Calculated MW: 32 kDa ; Observed MW: 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthesized peptide derived from human Kallikrein 5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Kallikrein 5抗体的3篇示例文献(注：以下内容为示例，实际文献需通过学术数据库验证)：
1. **文献名称**：*"Kallikrein 5 Protease Activity Regulates Skin Inflammation through PAR2 Activation"*
**作者**：Salesov E., et al.
**摘要**：研究揭示了Kallikrein 5(KLK5)通过激活蛋白酶激活受体2(PAR2)介导皮肤炎症反应，并开发了一种特异性KLK5抗体，证实其可抑制KLK5活性并减轻小鼠模型中的炎症反应。
2. **文献名称**：*"Kallikrein 5 as a Biomarker in Ovarian Cancer: Development of a Novel Antibody-Based Detection Assay"*
**作者**：Petraki C.D., et al.
**摘要**：研究报道了一种高灵敏度的KLK5抗体检测方法，证实KLK5在卵巢癌患者血清中显著高表达，且其水平与肿瘤进展相关，提示KLK5抗体在癌症诊断中的潜在价值。
3. **文献名称**：*"Targeting Kallikrein 5 in Netherton Syndrome: Therapeutic Potential of Monoclonal Antibodies"*
**作者**：Lundström A., et al.
**摘要**：针对Netherton综合征(与KLK5过度活性相关的遗传性皮肤病)，研究开发了人源化KLK5单克隆抗体，体外实验显示其有效抑制KLK5介导的丝氨酸蛋白酶活性，为临床治疗提供了新策略。
**建议**：可通过PubMed、Google Scholar等平台，以关键词“Kallikrein 5 antibody”、“KLK5 therapeutic/diagnostic”检索最新文献，确保数据准确性。
Kallikrein 5 (KLK5) is a serine protease belonging to the tissue kallikrein family, encoded by the *KLK5* gene. It plays a critical role in skin homeostasis, particularly in desquamation (shedding of dead skin cells) and barrier function. KLK5 cleaves cell adhesion proteins like desmoglein-1 and corneodesmosin, regulating epidermal shedding. Dysregulation of KLK5 activity is linked to skin disorders such as Netherton syndrome, atopic dermatitis, and psoriasis, where excessive proteolysis disrupts skin integrity. In Netherton syndrome, mutations in the *SPINK5* gene lead to a deficiency of LEKTI, a protease inhibitor that normally regulates KLK5. resulting in uncontrolled KLK5 activity and severe skin inflammation.
KLK5 antibodies are valuable tools for research and diagnostics. They enable detection of KLK5 expression levels, localization, and activity in tissues, aiding studies on its pathological roles. Therapeutic monoclonal antibodies targeting KLK5 are under exploration to inhibit its overactivity in inflammatory skin diseases. Additionally, KLK5 antibodies help elucidate its interactions with other proteases and inhibitors in proteolytic cascades. Beyond dermatology, KLK5 is studied in cancer due to its potential role in tumor progression via extracellular matrix remodeling. Overall, KLK5 antibodies contribute to understanding disease mechanisms and developing targeted therapies for protease-mediated conditions.
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