Rabbit Polyclonal ANO6(N-term) Antibody

The ANO6 (N-term) antibody is a specialized tool used to detect the N-terminal region of Anoctamin 6 (ANO6), a protein encoded by the *ANO6* gene in humans. ANO6 belongs to the anoctamin family, which comprises calcium-activated chloride channels and phospholipid scramblases. Unlike other family members like ANO1. ANO6 is primarily recognized for its role in phospholipid scrambling, a process critical for exposing phosphatidylserine on cell membranes during apoptosis, blood clotting, and membrane repair. It also participates in ion transport, though its channel activity remains less characterized. Dysregulation of ANO6 is linked to pathologies such as Scott syndrome (a rare bleeding disorder) and cancer metastasis. The ANO6 (N-term) antibody is commonly employed in research to study protein expression, localization, and function via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity for the N-terminal region allows researchers to distinguish ANO6 from other anoctamins, which share structural homology. Validation typically includes testing in knockout cell lines or tissues to confirm absence of non-specific binding. This antibody is particularly valuable in exploring ANO6’s dual roles in membrane dynamics and disease mechanisms, aiding studies in cell biology, hematology, and oncology. It is compatible with human, mouse, and rat samples, making it versatile for cross-species investigations.