| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CD61 antigen; GP3A; GPIIIa; ITB3; Platelet membrane glycoprotein IIIa |
| Entrez GeneID | 3690; |
| WB Predicted band size | 110kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 773 (P-L-Y(p)-K-E) derived from Human Integrin b3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Integrin β3 (Phospho-Tyr773)抗体的模拟参考文献示例(仅供格式参考，实际文献需通过学术数据库检索确认)：
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1. **"Phosphorylation of Integrin β3 at Tyr773 regulates platelet adhesion and thrombus stability"**
*Authors: Smith A, et al.*
摘要：本研究通过使用Phospho-Tyr773特异性抗体，发现Integrin β3在Tyr773位点的磷酸化增强了血小板与纤维蛋白原的结合能力，并促进血栓形成中的信号传导。
2. **"Tyr773 phosphorylation of Integrin β3 modulates tumor cell invasion via FAK signaling"**
*Authors: Chen L, et al.*
摘要：利用Phospho-Tyr773抗体进行免疫印迹分析，揭示该位点的磷酸化通过激活FAK通路，增强肿瘤细胞的迁移和侵袭能力，提示其作为癌症治疗的潜在靶点。
3. **"Role of Integrin β3 tyrosine phosphorylation in angiogenesis"**
*Authors: Wang Y, et al.*
摘要：通过免疫荧光和共聚焦显微镜技术，证明内皮细胞中Integrin β3的Tyr773磷酸化调控VEGF诱导的血管生成，并影响细胞外基质重塑。
4. **"Mechanistic insights into Integrin β3 phosphorylation-dependent osteoclast adhesion"**
*Authors: Tanaka K, et al.*
摘要：使用Phospho-Tyr773抗体研究发现，该磷酸化事件通过调节RhoA/ROCK通路，影响破骨细胞黏附结构和骨吸收功能。
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**注意**：以上文献为模拟示例，具体研究需查阅PubMed、Google Scholar等数据库获取真实文献(可检索关键词：**Integrin β3 phosphorylation Tyr773 antibody**)。实际应用中需验证抗体货号(如CST #13166)及文献准确性。
Integrin β3 (Phospho-Tyr773) antibody is a specialized tool used to detect the phosphorylated form of integrin β3 at tyrosine residue 773. Integrin β3. a subunit of the heterodimeric transmembrane receptor family, pairs with α subunits (e.g., αIIb or αv) to form receptors like αIIbβ3 (platelets) and αvβ3 (endothelial/tumor cells). These receptors mediate cell adhesion, migration, and signaling by interacting with extracellular matrix proteins or counter-receptors. Phosphorylation at Tyr773 is a critical post-translational modification associated with integrin activation, outside-in signaling, and regulation of cellular processes such as cytoskeletal reorganization, platelet aggregation, and angiogenesis.
This phosphorylation event often occurs in response to stimuli like growth factors, shear stress, or ligand binding, modulating interactions with signaling adaptors (e.g., Src kinases, talin). Dysregulation of integrin β3 phosphorylation is implicated in pathologies, including thrombosis, cancer metastasis, and inflammatory disorders. The antibody is widely utilized in research to study integrin activation states, signal transduction mechanisms, or disease biomarkers. Applications include Western blotting, immunofluorescence, or immunohistochemistry to assess phosphorylation dynamics in cell lines, tissues, or disease models. Specificity validation (e.g., via knockout controls or phosphatase treatment) is essential due to potential cross-reactivity with other phosphorylated tyrosine residues. Understanding Tyr773 phosphorylation aids in elucidating integrin-related pathways and therapeutic targeting in vascular or oncological research.
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