Rabbit Polyclonal BCL-2(Phospho-Ser70) Antibody

The BCL-2 (Phospho-Ser70) antibody is a crucial tool for studying the post-translational regulation of BCL-2. an anti-apoptotic protein central to mitochondrial apoptosis pathways. BCL-2 prevents apoptosis by inhibiting pro-apoptotic BAX/BAK activation and maintaining mitochondrial membrane integrity. Phosphorylation at Ser70. a key regulatory modification, enhances BCL-2’s anti-apoptotic activity and is associated with survival signaling in response to growth factors or stress. This modification may stabilize BCL-2’s interaction with pro-apoptotic proteins or alter its conformation. The antibody specifically detects phosphorylated Ser70. enabling researchers to investigate BCL-2 activation in contexts like cancer, chemoresistance, and cellular survival mechanisms. It is widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to assess phosphorylation status in cell lines, tissues, or clinical samples. Dysregulated BCL-2 phosphorylation is linked to tumor progression and therapeutic resistance, making this antibody valuable for both basic research and translational studies targeting apoptosis pathways. Validation includes testing in knockout models or phosphorylation-deficient mutants to ensure specificity.