Rabbit Polyclonal G3BP-1(Phospho-Ser232) Antibody

The G3BP-1 (Phospho-Ser232) antibody is a specialized tool used to detect the phosphorylated form of G3BP-1 (Ras GTPase-activating protein-binding protein 1) at serine residue 232. G3BP-1 is a multifunctional RNA-binding protein critical for stress granule (SG) assembly, which serves as dynamic cytoplasmic condensates that sequester untranslated mRNAs during cellular stress. Phosphorylation at Ser232 is a key regulatory post-translational modification influencing G3BP-1’s role in stress response pathways. This modification is often triggered by stress signals (e.g., oxidative stress, viral infection) or inhibited kinases, modulating G3BP-1’s ability to nucleate SGs by altering its interactions with other proteins or RNA. The antibody is widely employed in techniques like Western blotting and immunofluorescence to study SG dynamics, stress response mechanisms, and conditions like viral replication, neurodegeneration, or cancer. Its specificity for the phosphorylated epitope makes it valuable for exploring kinase-mediated regulation of G3BP-1. particularly in contexts involving PKR or eIF2α signaling. Researchers use this antibody to dissect how stress-induced phosphorylation impacts cellular adaptation, translation arrest, and disease pathogenesis.