关键信息
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基因名
ITGb3
- 应用
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别名
ITGb3；GP3A；Integrin beta-3
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P05106
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表达区间
1-788aa
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氨基酸序列
MRARPRPRPLWATVLALGALAGVGVGGPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT
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蛋白长度
Full Length
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分子量
87 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
ITGb3, or integrin beta 3, is a key component of integrin receptors, which play vital roles in cell adhesion, signaling, and the extracellular matrix's interaction with various cell types. Research into ITGb3 has gained momentum due to its significant implications in several physiological and pathological processes, including thrombosis, inflammation, and cancer metastasis. Integrins, as transmembrane receptors, facilitate communication between the inside of the cell and its external environment, thereby influencing cell behavior. Dysregulation of ITGb3 has been linked to various diseases, particularly in oncology, where it contributes to tumor progression and metastasis. Moreover, ITGb3 serves as a receptor for various ligands, such as fibrinogen and von Willebrand factor, making it a target for therapeutic interventions. The recombinant protein studies of ITGb3 focus on elucidating its structure-function relationships, understanding its role in cellular interactions, and developing targeted treatments that could inhibit its activity in pathological conditions. Advances in recombinant DNA technology and protein engineering have facilitated the production of ITGb3 variants, enabling detailed investigations into its functions and interactions, thereby revealing potential strategies to modulate its activity in disease contexts. As such, ITGb3 represents a promising target for therapeutic development, with ongoing research aimed at exploring novel inhibitors and their implications for improving clinical outcomes in various diseases.
