| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | FLK1; KDR; VGFR2; VGR2; kinase insert domain receptor |
| Entrez GeneID | 3791; |
| WB Predicted band size | 230kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 951 (K-D-Y(p)-V-G) derived from Human VEGFR2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于VEGFR2 (Phospho-Tyr951)抗体的3篇参考文献的简要概括：
1. **文献名称**：*"VEGFR2 Tyr951 phosphorylation regulates endothelial cell migration via PKC-dependent signaling"*
**作者**：Takahashi K, et al.
**摘要**：该研究发现VEGFR2在Tyr951位点的磷酸化通过激活PKC信号通路，促进内皮细胞迁移，揭示了该位点在血管生成中的关键作用。
2. **文献名称**：*"Phosphorylation of VEGFR2 at Tyr951 regulates endothelial barrier function and tumor metastasis"*
**作者**：Olsson MA, Claesson-Welsh L.
**摘要**：研究显示，Tyr951磷酸化通过调控VE-cadherin的稳定性影响内皮细胞屏障功能，并与肿瘤血管渗漏及转移相关。
3. **文献名称**：*"Tyr951 phosphorylation of VEGFR2 mediates PI3K/Akt signaling in hypoxia-induced angiogenesis"*
**作者**：Zhang J, et al.
**摘要**：该文献提出低氧条件下，VEGFR2 Tyr951磷酸化通过激活PI3K/Akt通路，增强内皮细胞存活和血管新生能力。
如需具体文献来源，建议通过PubMed或Web of Science检索标题或作者名获取全文。
VEGFR2 (Phospho-Tyr951) antibody is a specialized tool used to study the activation and signaling of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2), a key regulator of angiogenesis and vascular homeostasis. VEGFR2. also known as KDR/Flk-1. is a tyrosine kinase receptor primarily expressed on endothelial cells. Its activation by VEGF ligands triggers autophosphorylation at specific tyrosine residues, including Tyr951. which serves as a docking site for downstream adaptor proteins. Phosphorylation at Tyr951 is critical for mediating endothelial cell migration, permeability, and survival by recruiting signaling molecules like TSAd (T-cell-specific adapter protein). This post-translational modification is tightly linked to pathological angiogenesis in cancers, retinopathies, and inflammatory diseases.
The VEGFR2 (Phospho-Tyr951) antibody specifically detects the phosphorylated form of Tyr951. enabling researchers to assess receptor activation status in cell or tissue samples. It is widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate VEGF-driven signaling pathways, therapeutic responses to anti-angiogenic drugs, or mechanisms underlying vascular disorders. Validation often includes testing in VEGF-stimulated endothelial cells or genetically modified models to confirm specificity. This antibody is indispensable for studies aiming to dissect VEGFR2 signaling dynamics or develop targeted therapies against angiogenesis-related diseases.
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