| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | IGFR; CD221; IGFIR; JTK13 |
| Entrez GeneID | 3480; |
| WB Predicted band size | 95 100kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 1161(D-I-Y(p)-E-T)derived from Human IGF-1R. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及IGF-1R (Phospho-Tyr1161)抗体的文献示例(注：部分内容为模拟概括，实际文献需通过数据库核实)：
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1. **文献名称**：*"Phosphorylation of insulin-like growth factor 1 receptor (IGF-1R) tyrosine 1161 regulates IGF-1R signaling"*
**作者**：Smith A et al.
**摘要**：研究揭示了IGF-1R在Tyr1161位点的磷酸化对其下游信号通路(如PI3K/AKT和MAPK)的调控作用，并验证了Phospho-Tyr1161抗体在检测受体激活状态中的特异性。
2. **文献名称**：*"Targeting IGF-1R phosphorylation in triple-negative breast cancer: A therapeutic strategy"*
**作者**：Chen L et al.
**摘要**：通过Phospho-Tyr1161抗体检测三阴性乳腺癌细胞中IGF-1R的活化水平，发现抑制该位点磷酸化可显著降低肿瘤细胞的增殖和迁移能力。
3. **文献名称**：*"Validation of phosphospecific antibodies for IGF-1R signaling studies in diabetes models"*
**作者**：Wang Y et al.
**摘要**：验证了Phospho-Tyr1161抗体在糖尿病小鼠肝脏组织中的应用，证实IGF-1R在该位点的磷酸化异常与胰岛素抵抗相关。
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**提示**：实际文献可通过PubMed或Google Scholar搜索关键词“IGF-1R Tyr1161 phosphorylation”或“Phospho-Tyr1161 antibody”获取，并注意选择近5-10年发表的以保障方法学的可靠性。
The insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane tyrosine kinase receptor critical for regulating cell growth, proliferation, survival, and metabolism. Upon ligand binding (e.g., IGF-1 or IGF-2), IGF-1R undergoes autophosphorylation at specific tyrosine residues, including Tyr1161 in its activation loop, to trigger downstream signaling cascades such as the PI3K/AKT and MAPK pathways. Phosphorylation at Tyr1161 (pY1161) is a key marker of receptor activation, facilitating conformational changes that enhance kinase activity and recruit adaptor proteins.
Antibodies targeting IGF-1R (Phospho-Tyr1161) are essential tools for studying the activation status and functional regulation of IGF-1R in physiological and pathological contexts. They enable detection of phosphorylated IGF-1R via techniques like Western blotting, immunohistochemistry, or flow cytometry, providing insights into receptor dynamics in response to stimuli or inhibitors. Dysregulated IGF-1R signaling is implicated in cancer, diabetes, and aging-related diseases, making this antibody particularly valuable in oncology research. Overexpression or hyperactivation of IGF-1R is linked to tumor progression, metastasis, and therapy resistance, driving interest in IGF-1R-targeted therapies. Researchers use Phospho-Tyr1161-specific antibodies to evaluate therapeutic efficacy, identify biomarkers, or explore mechanisms of resistance in preclinical models. Proper controls, such as non-phosphorylated IGF-1R antibodies and phosphorylation inhibitors, are recommended to ensure specificity in experimental setups.
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