Rabbit Polyclonal Niban-likeprotein(Phospho-Ser712) Antibody

中文名： Niban-like protein(Phospho-Ser712)抗体
别名： C9orf88

货号: IPDX40300

Price： ￥1280

50μl 100μl

数量：

大包装询价

验证与应用

应用及物种

WB	咨询技术	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	咨询技术	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	咨询技术	Human,Mouse,Rat

产品详情

Aliases	C9orf88
Entrez GeneID	64855;
WB Predicted band size	80kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around phosphorylation site of serine 712 (Q-V-S-S(p)-P) derived from Human Niban-like protein.
Formulation	Purified antibody in PBS with 0.05% sodium azide.

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Western blot analysis of extracts from A172 cells using Niban-like protein(Phospho-Ser712) Antibody P40300.

参考文献

以下是关于Niban-like protein(Phospho-Ser712)抗体的参考文献示例(内容为虚构，仅供格式参考)：

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1. **文献名称**：*Phosphorylation of Niban-like protein at Ser712 regulates apoptosis in colorectal cancer cells*

**作者**：Smith A, et al.

**摘要**：本研究揭示了FAM129A(Niban-like蛋白)在结直肠癌细胞中Ser712位点的磷酸化通过抑制caspase-3活性调控细胞凋亡的机制，并开发了特异性Phospho-Ser712抗体用于磷酸化水平检测。

2. **文献名称**：*ERK-dependent phosphorylation of FAM129A at Ser712 promotes tumor cell migration*

**作者**：Chen L, et al.

**摘要**：作者证实ERK信号通路介导的FAM129A Ser712磷酸化可增强其与14-3-3蛋白的结合，从而促进乳腺癌细胞迁移。研究利用Phospho-Ser712抗体进行免疫印迹和免疫荧光分析。

3. **文献名称**：*A novel phospho-specific antibody reveals the role of Niban-like protein in oxidative stress response*

**作者**：Yamamoto K, et al.

**摘要**：本文开发了一种高特异性Phospho-Ser712抗体，发现FAM129A在氧化应激下发生磷酸化，并通过调控Nrf2通路增强细胞存活能力，为癌症治疗提供潜在靶点。

4. **文献名称**：*Ser712 phosphorylation of FAM129A modulates its interaction with ubiquitin ligases in prostate cancer*

**作者**：Johnson R, et al.

**摘要**：研究通过Phospho-Ser712抗体发现，前列腺癌中FAM129A的磷酸化修饰影响其与E3泛素连接酶的相互作用，导致蛋白稳定性升高并促进肿瘤进展。

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注：以上文献为示例性质，实际研究中请通过PubMed等数据库检索真实发表的论文。

背景信息

The Niban-like protein, also known as FAM129B, is a member of the FAM129 family implicated in cellular stress response, apoptosis regulation, and cancer progression. Phosphorylation at Ser712 (Ser713 in some isoforms) is a critical post-translational modification modulating its function. This phosphorylation event, often mediated by kinases such as MAPK/ERK, enhances FAM129B's interaction with 14-3-3 proteins, influencing its subcellular localization, stability, and activity.

The Niban-like protein (Phospho-Ser712) antibody is a specialized tool designed to detect this phosphorylation state, enabling researchers to study FAM129B's role in signaling pathways under stress or oncogenic conditions. FAM129B is overexpressed in various cancers, including melanoma and prostate cancer, and its phosphorylation status correlates with tumor aggressiveness and therapeutic resistance. The antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess phosphorylation dynamics in cell lines, tissues, or preclinical models. Its specificity for the phosphorylated epitope allows precise investigation of pathway activation, particularly in studies exploring crosstalk between stress-adaptive responses and survival mechanisms. Validation typically includes knockout cell controls or peptide competition assays to ensure reliability. Research utilizing this antibody contributes to understanding how FAM129B phosphorylation drives cancer metastasis, metabolic reprogramming, or resistance to targeted therapies, offering potential insights for biomarker discovery or therapeutic targeting.