Rabbit Polyclonal TISB(Phospho-Ser92) Antibody

The TISB (Phospho-Ser92) antibody is designed to detect the phosphorylated form of the protein TIS11B (also known as ZFP36L1) at serine residue 92. TIS11B belongs to the ZFP36 family of RNA-binding proteins, which regulate gene expression post-transcriptionally by binding to AU-rich elements (AREs) in the 3'-untranslated regions (3'-UTRs) of target mRNAs, promoting their degradation or translational repression. This protein plays critical roles in immune response, cell differentiation, and apoptosis. Phosphorylation at Ser92 is a key regulatory modification that modulates TIS11B activity, potentially influencing its subcellular localization, RNA-binding affinity, or interaction with other proteins. Dysregulation of TIS11B has been implicated in inflammatory diseases, cancer, and autoimmune disorders. The TISB (Phospho-Ser92) antibody is widely used in research to investigate signaling pathways involving TIS11B activation, particularly in contexts like cellular stress, cytokine signaling, or oncogenic transformations. It enables specific detection of the phosphorylated protein via techniques such as Western blotting, immunofluorescence, or immunoprecipitation, aiding studies on post-translational regulation of mRNA stability and its physiological or pathological implications.