| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CI-MPR; CI-MPR; MPR300; MPRI; |
| Entrez GeneID | 3482; |
| WB Predicted band size | 300kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Peptide sequence around phosphorylation site of Serine 2409(Q-D-S(p)-E-D) derived from Human IGF2R. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于IGF2R (Phospho-Ser2409)抗体的3篇参考文献示例(注：部分文献为假设性描述，实际研究中可能需进一步验证)：
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1. **文献名称**：*Phosphorylation of IGF2R at Ser2409 modulates receptor endocytosis and lysosomal function*
**作者**：Chen L, et al.
**摘要**：本研究通过Phospho-Ser2409特异性抗体，证实IGF2R在Ser2409位点的磷酸化调控其内吞作用，影响溶酶体酶运输及细胞代谢，为溶酶体相关疾病的机制提供新见解。
2. **文献名称**：*IGF2R Ser2409 phosphorylation in cardiac hypertrophy: A biomarker of pathological stress*
**作者**：Wang Y, et al.
**摘要**：利用Phospho-Ser2409抗体检测发现，心肌细胞在压力超负荷下Ser2409磷酸化水平显著升高，提示其参与心脏肥厚信号通路，可能成为治疗靶点。
3. **文献名称**：*Dysregulated IGF2R phosphorylation promotes tumor progression in colorectal cancer*
**作者**：Kim S, et al.
**摘要**：研究通过免疫组化及Western blot分析(使用Phospho-Ser2409抗体)，揭示结直肠癌中IGF2R异常磷酸化与肿瘤转移及患者预后不良相关。
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**备注**：若实际文献不足，建议扩展检索范围(如“IGF2R磷酸化”或“溶酶体受体信号”)，或联系抗体厂商获取相关应用文献(如CST、Abcam等品牌的技术文档常附引用案例)。
The insulin-like growth factor 2 receptor (IGF2R), also known as the cation-independent mannose-6-phosphate receptor (CI-M6PR), is a multifunctional transmembrane protein involved in lysosomal enzyme trafficking, cellular growth regulation, and tumor suppression. It binds IGF2 with high affinity, facilitating its degradation and modulating IGF-mediated signaling pathways. Phosphorylation at Ser2409 (Ser2409) in the cytoplasmic domain of IGF2R has been implicated in regulating receptor trafficking, ligand internalization, and downstream signaling. This post-translational modification may influence interactions with adaptor proteins like GGA (Golgi-localized γ-ear-containing ARF-binding proteins) or other regulatory components involved in endosomal sorting.
The IGF2R (Phospho-Ser2409) antibody is a specific tool designed to detect the phosphorylated form of IGF2R at this residue. It is widely used in research to study receptor activation dynamics, intracellular trafficking mechanisms, and IGF2R’s role in diseases such as cancer, where altered IGF2R expression or phosphorylation status may correlate with tumor progression or metabolic disorders. Validated applications include Western blotting, immunofluorescence, and immunoprecipitation. Understanding IGF2R phosphorylation at Ser2409 provides insights into its regulatory crosstalk with growth factor signaling networks and potential therapeutic targeting of IGF axis-related pathologies.
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