Rabbit Polyclonal PDK1(Phospho-Tyr9) Antibody

The PDK1 (Phospho-Tyr9) antibody is a specialized tool used to detect the phosphorylated form of 3-phosphoinositide-dependent protein kinase 1 (PDK1) at tyrosine residue 9. PDK1 is a serine/threonine kinase critical for signaling pathways regulating cell growth, survival, and metabolism, primarily through activation of downstream AGC kinase family members like Akt/PKB. Phosphorylation at Tyr9 is a key post-translational modification implicated in modulating PDK1 activity, localization, or interactions with other signaling components. While PDK1 is best known for its activation via phosphorylation at serine/threonine residues (e.g., Ser241 in the kinase domain), tyrosine phosphorylation sites, including Tyr9. have gained attention for their potential regulatory roles in specific contexts, such as growth factor or insulin signaling. The PDK1 (Phospho-Tyr9) antibody enables researchers to study this modification under physiological or pathological conditions, including cancer, diabetes, or neurological disorders. Its specificity is validated for recognizing the phosphorylated Tyr9 epitope, often through techniques like Western blotting, immunoprecipitation, or immunofluorescence. This antibody supports investigations into how Tyr9 phosphorylation fine-tunes PDK1 function, impacts downstream pathways (e.g., PI3K/Akt/mTOR), and contributes to disease mechanisms.