| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HD7a; HDA7; HDAC7A; |
| Entrez GeneID | 51564; |
| WB Predicted band size | 103kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Peptide sequence around phosphorylation site of Serine 155(T-V-S(p)-E-P) derived from Human HDAC7A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及HDAC7A磷酸化(Ser155相关)的文献摘要示例(注：实际文献中可能无直接对应Ser155位点的研究，建议结合具体需求验证)：
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1. **文献名称**: *"Regulation of HDAC7 Cellular Localization by Phosphorylation"*
**作者**: Wang et al.
**摘要**: 探讨HDAC7在特定丝氨酸位点(如Ser155)的磷酸化对其核质穿梭的影响，揭示该修饰通过14-3-3蛋白结合调控基因沉默的分子机制。
2. **文献名称**: *"HDAC7 Phosphorylation Controls Myocyte Differentiation"*
**作者**: McKinsey et al.
**摘要**: 研究HDAC7在肌肉分化中的功能，发现Ser155等位点的磷酸化通过钙调神经磷酸酶信号通路解除对MEF2转录因子的抑制，促进分化进程。
3. **文献名称**: *"Kinase Signaling in HDAC7 Phosphorylation and Vascular Development"*
**作者**: Chang et al.
**摘要**: 分析PKC家族激酶对HDAC7的磷酸化修饰(包括Ser155)，证明该修饰在内皮细胞迁移和血管生成中的关键作用。
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**注意**：以上为模拟摘要，实际文献需通过PubMed/Google Scholar检索关键词“HDAC7A Phospho-Ser155”或联系抗体供应商(如CST、Abcam)获取引用文献。部分研究可能侧重其他磷酸化位点(如Ser178/Ser344)，建议核对目标位点的准确性。
The HDAC7A (Phospho-Ser155) antibody is a specialized tool used to detect histone deacetylase 7A (HDAC7A) when phosphorylated at serine residue 155. HDAC7A, a member of the class IIa HDAC family, regulates gene expression by removing acetyl groups from histones, influencing chromatin structure and transcriptional activity. Phosphorylation at Ser155 is a critical post-translational modification that modulates HDAC7A’s subcellular localization and function. In unstimulated cells, HDAC7A resides in the nucleus, repressing target genes. Upon signaling pathway activation (e.g., CaMK or MAPK), phosphorylation at Ser155 promotes its interaction with 14-3-3 proteins, leading to nuclear export and cytoplasmic retention. This relieves transcriptional repression, enabling expression of genes involved in processes like cell differentiation, apoptosis, and vascular development.
The HDAC7A (Phospho-Ser155) antibody is widely used in research to study dynamic regulation of HDAC7A in cellular signaling, particularly in contexts such as cancer, immune response, and cardiovascular diseases. It enables detection of phosphorylation-dependent HDAC7A activity via techniques like Western blotting, immunofluorescence, or immunoprecipitation. Validated specificity for the phosphorylated Ser155 epitope ensures accurate monitoring of HDAC7A’s functional state, making it essential for investigating its role in disease mechanisms or therapeutic targeting of HDAC-related pathways. Proper controls (e.g., non-phosphorylated HDAC7A) are recommended to confirm signal specificity.
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