Rabbit Polyclonal YB1(Phospho-Ser102) Antibody

The YB1 (Phospho-Ser102) antibody is a specialized tool used to detect the phosphorylation of Y-box binding protein 1 (YB1) at serine residue 102. a post-translational modification critical for regulating YB1's functional dynamics. YB1. a member of the cold-shock domain protein family, plays multifaceted roles in DNA/RNA binding, transcriptional regulation, mRNA translation, and cellular stress responses. Its activity is tightly modulated by phosphorylation, which alters its subcellular localization and interactions. Phosphorylation at Ser102. mediated by kinases such as AKT or RSK, triggers YB1's nuclear translocation, where it activates pro-survival or proliferative genes, including those linked to cancer progression, drug resistance, and epithelial-mesenchymal transition (EMT). This modification is particularly studied in oncology, as hyperphosphorylated YB1 is associated with aggressive tumor behavior and poor prognosis. The YB1 (Phospho-Ser102) antibody enables researchers to investigate this regulatory mechanism in models of carcinogenesis, metastasis, and therapeutic resistance. It is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess phosphorylation-dependent YB1 activation in cell lines or clinical samples. Understanding YB1 phosphorylation dynamics provides insights into targeted therapies aiming to disrupt oncogenic signaling pathways.