| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HTATIP; TI60; Tat-interactive protein-60; |
| Entrez GeneID | 10524; |
| WB Predicted band size | 58kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of Serine 90(P-G-S(p)-P-E) derived from Human Tip60. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Tip6(Phospho-Ser90)抗体的3篇代表性文献(注：Tip6蛋白相关研究较少，以下内容为模拟示例)：
1. **"Phosphorylation of Tip6 at Ser90 regulates microtubule dynamics in mitotic progression"**
- **作者**: Zhang L et al.
- **摘要**: 本研究报道了Tip6蛋白在Ser90位点的磷酸化修饰通过调控微管稳定性影响有丝分裂进程，并开发了特异性识别该磷酸化位点的抗体，验证了其在细胞周期中的动态变化。
2. **"A novel phospho-specific antibody reveals Tip6-Ser90 phosphorylation in DNA damage response"**
- **作者**: Tanaka K et al.
- **摘要**: 文章描述了一种针对Tip6-Ser90磷酸化位点的单克隆抗体的制备与验证，发现该修饰在DNA损伤修复中通过ATM激酶途径被激活，可能与染色体重塑相关。
3. **"Functional characterization of Tip6 phosphorylation in neuronal differentiation"**
- **作者**: Chen R et al.
- **摘要**: 利用Phospho-Ser90抗体，研究发现Tip6在神经元分化过程中Ser90磷酸化水平显著上调，且通过调控MAPK信号通路影响突触可塑性。
**备注**：以上文献为示例，实际研究中Tip6蛋白的命名及磷酸化位点需根据具体物种和上下文确认。建议通过PubMed或抗体供应商(如CST、Abcam)的产品引用列表获取真实文献。
The Tip6 (Phospho-Ser90) antibody is designed to detect the phosphorylated form of Thyroid hormone receptor-interacting protein 6 (TIP6/TRIP6) at serine residue 90. TIP6. a member of the LIM domain-containing protein family, plays a role in cell adhesion, migration, and signal transduction by interacting with cytoskeletal components and signaling molecules like FAK and Src kinases. Phosphorylation at Ser90 is a critical post-translational modification that regulates TIP6’s functional dynamics. This modification is often induced by cellular stimuli such as mechanical stress, growth factors, or integrin activation, and it influences TIP6’s ability to shuttle between the cytoplasm and nucleus, modulating gene expression or cytoskeletal reorganization.
The Tip6 (Phospho-Ser90) antibody is widely used in studies exploring mechanotransduction, cancer metastasis, or inflammatory responses, as aberrant TIP6 phosphorylation has been linked to tumor progression and pathological cell motility. Researchers employ this antibody in techniques like Western blotting, immunofluorescence, or immunohistochemistry to assess phosphorylation-dependent TIP6 activation in cellular or tissue samples. Specificity validation, including knockout controls or phosphatase treatment, is essential to confirm the antibody’s accuracy. Understanding Ser90 phosphorylation provides insights into TIP6’s dual roles in transcriptional regulation and cytoskeletal signaling, making this antibody a valuable tool in cell biology and disease research.
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