Rabbit Polyclonal TOB1(Phospho-Ser164) Antibody

The TOB1 (Phospho-Ser164) antibody is designed to detect the phosphorylation of the TOB1 protein at serine residue 164 (Ser164). TOB1 (Transducer of ERBB2 1) is a member of the TOB/BTG family of anti-proliferative proteins, which regulate cell cycle progression and act as tumor suppressors. It interacts with transcriptional regulators (e.g., Caf1 deadenylase) and ubiquitin ligases to modulate mRNA stability, protein degradation, and signaling pathways. Phosphorylation at Ser164 is a critical post-translational modification linked to TOB1's functional regulation. Studies suggest that this modification may influence TOB1's ability to suppress cell growth, potentially by altering its interactions with binding partners or subcellular localization. The phosphorylation event is associated with signaling pathways involving kinases such as ERK or cyclin-dependent kinases (CDKs), which are often dysregulated in cancers. Researchers use the TOB1 (Phospho-Ser164) antibody in techniques like Western blotting, immunofluorescence, or immunoprecipitation to study its role in cell cycle control, cancer biology (e.g., breast, gastric, or lung cancers), and interactions with oncogenic pathways. Its expression and phosphorylation status may serve as biomarkers for disease progression or therapeutic targeting.