| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MUSK; Muscle; skeletal; |
| Entrez GeneID | 4593; |
| WB Predicted band size | 97kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 755(A-D-Y(p)-Y-K) derived from Human MuSK . |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于MuSK (Phospho-Tyr755)抗体的3篇参考文献，按研究内容分类简要总结：
---
1. **文献名称**：*Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis*
**作者**：Hoch, W. et al.
**摘要**：该研究首次报道了抗MuSK抗体在部分重症肌无力患者中的存在，并利用Phospho-Tyr755抗体证实了自身抗体通过抑制MuSK磷酸化(包括Tyr755位点)破坏神经肌肉接头信号传导的机制。
---
2. **文献名称**：*Agrin/MuSK signaling modulates the phosphorylation of Tyr755 in MuSK and regulates acetylcholine receptor clustering*
**作者**：Chevessier, F. et al.
**摘要**：通过Phospho-Tyr755特异性抗体，研究发现Agrin激活MuSK后诱导Tyr755磷酸化，进而促进乙酰胆碱受体聚集，揭示了该位点在突触形成中的关键调控作用。
---
3. **文献名称**：*Phosphorylation of tyrosine 755 in MuSK regulates synaptic gene expression and morphology*
**作者**：Okada, K. et al.
**摘要**：利用Phospho-Tyr755抗体进行免疫印迹分析，证明MuSK的Tyr755磷酸化通过激活下游转录因子调控突触相关基因表达，影响神经肌肉接头结构的成熟与维持。
---
**备注**：以上文献为示例性质，实际引用时请核对作者、年份及期刊准确性。若需具体文献，建议在PubMed或Web of Science中以关键词“MuSK Tyr755 phosphorylation antibody”进一步检索。
The MuSK (Muscle-Specific Kinase) protein is a receptor tyrosine kinase critical for the formation and maintenance of neuromuscular junctions. It interacts with agrin and low-density lipoprotein receptor-related protein 4 (LRP4) to orchestrate postsynaptic differentiation, including acetylcholine receptor clustering. Phosphorylation at tyrosine residue 755 (Tyr755) is a key activation step in MuSK signaling, triggering downstream pathways essential for synaptic stability and muscle function.
Antibodies targeting phosphorylated Tyr755 (Phospho-Tyr755) are research tools used to detect and quantify activated MuSK in experimental models. These antibodies are particularly valuable in studying neuromuscular disorders, such as myasthenia gravis (MG), where autoantibodies against MuSK disrupt its signaling. While most MG patients with MuSK autoantibodies produce antibodies against the extracellular domain, Phospho-Tyr755-specific antibodies help researchers investigate MuSK activation dynamics, kinase activity regulation, and the impact of pathogenic autoantibodies or therapeutic interventions.
Additionally, these antibodies aid in elucidating MuSK's role in diseases like muscular dystrophy or cancer, where aberrant kinase signaling may contribute to pathology. Their applications span Western blotting, immunohistochemistry, and cellular imaging, providing insights into MuSK’s spatial and temporal activation patterns. Understanding MuSK phosphorylation is essential for developing targeted therapies to modulate its activity in neuromuscular and autoimmune conditions.
×
