| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | ITGB1; FNRB; MDF2; MSK12; Integrin beta-1; Fibronectin receptor subunit beta; VLA-4 subunit beta; CD antigen CD29 |
| Entrez GeneID | 3688; |
| WB Predicted band size | 135kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from human Integrin β1 around the phosphorylation site of T788. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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1. **文献名称**: "Phosphorylation of Integrin β1 at Thr788 Regulates Cell Migration and Invasion"
**作者**: Zhang et al.
**摘要**: 该研究通过免疫沉淀和Western blot分析，揭示了Integrin β1 Thr788位点的磷酸化在肿瘤细胞迁移和侵袭中的关键作用，并验证了该抗体的特异性。
2. **文献名称**: "Integrin β1 Thr788 Phosphorylation Modulates Extracellular Matrix Remodeling"
**作者**: Lee et al.
**摘要**: 研究利用Phospho-Thr788抗体发现，该位点的磷酸化通过激活FAK/Src信号通路促进细胞外基质重塑，影响乳腺癌细胞转移。
3. **文献名称**: "Role of Integrin β1 Thr788 Phosphorylation in Fibrosis Development"
**作者**: Chen et al.
**摘要**: 通过免疫组织化学和功能实验，证明Thr788磷酸化抗体可特异性标记纤维化组织中的激活Integrin β1.揭示其在纤维化病理进程中的调控机制。
4. **文献名称**: "A Novel Phospho-Specific Antibody for Integrin β1 Thr788 in Neuronal Differentiation"
**作者**: Smith et al.
**摘要**: 开发并验证了一种高特异性Phospho-Thr788抗体，证明其在神经元分化过程中通过调节Integrin β1信号促进轴突生长。
Integrin β1 (Phospho-Thr788) antibody is a specialized tool used to detect the phosphorylated form of Integrin β1 at threonine residue 788. a post-translational modification critical for regulating integrin-mediated cellular processes. Integrin β1. a subunit of the heterodimeric integrin receptor family, plays a central role in cell adhesion, migration, and signal transduction by connecting the extracellular matrix (ECM) to the cytoskeleton. Phosphorylation at Thr788 occurs in the cytoplasmic domain of Integrin β1 and is associated with receptor activation, conformational changes, and downstream signaling events. This modification modulates interactions with cytoskeletal proteins and signaling adaptors, influencing pathways such as FAK (focal adhesion kinase) and Src kinase cascades, which regulate cell survival, proliferation, and motility.
The antibody is widely utilized in research to investigate integrin activation dynamics, particularly in contexts like cancer metastasis, tissue fibrosis, and inflammatory diseases, where aberrant integrin signaling is implicated. By specifically recognizing the phosphorylated Thr788 epitope, it enables the detection of Integrin β1 activation status in techniques such as Western blotting, immunofluorescence, and immunohistochemistry. Studies using this antibody have shed light on how phosphorylation at this site correlates with disease progression, offering potential insights into therapeutic targeting of integrin pathways. Its application helps dissect the molecular mechanisms underlying cell-ECM interactions and their pathological disruptions.
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