Rabbit Polyclonal DNAM-1(Phospho-Ser329) Antibody

The DNAM-1 (Phospho-Ser329) antibody is a specialized tool used to detect the phosphorylated form of DNAX accessory molecule-1 (DNAM-1/CD226) at serine residue 329. DNAM-1 is a transmembrane glycoprotein expressed on immune cells, including T cells, natural killer (NK) cells, and platelets. It plays a critical role in regulating immune responses by interacting with ligands such as CD155 (PVR) and CD112 (Nectin-2) on target cells, facilitating cell adhesion, activation, and cytotoxicity. Phosphorylation of DNAM-1 at Ser329 is linked to its functional modulation, potentially influencing downstream signaling pathways or receptor-ligand interactions. This post-translational modification may serve as a regulatory mechanism to fine-tune immune cell activity in contexts like tumor surveillance, viral infection, or autoimmune disorders. The antibody is commonly employed in research to study DNAM-1 activation states, signaling dynamics, and its role in immune regulation. Its applications include Western blotting, immunofluorescence, and flow cytometry, enabling insights into phosphorylation-dependent mechanisms underlying DNAM-1-mediated immune responses. Understanding Ser329 phosphorylation could inform therapeutic strategies targeting immune checkpoint pathways.