Rabbit Polyclonal PP2A-Cα(Phospho-Tyr307) Antibody

The PP2A-Cα (Phospho-Tyr307) antibody is a specialized tool used to detect the phosphorylation status of protein phosphatase 2A (PP2A) catalytic subunit alpha (PP2A-Cα) at tyrosine residue 307. PP2A is a critical serine/threonine phosphatase involved in regulating diverse cellular processes, including cell cycle progression, signal transduction, and apoptosis. The PP2A holoenzyme comprises a catalytic subunit (C), a structural scaffold subunit (A), and a variable regulatory subunit (B), with PP2A-Cα being a predominant isoform of the catalytic subunit. Phosphorylation at Tyr307 is a key post-translational modification that modulates PP2A activity and substrate specificity. This modification is linked to the inhibition of PP2A function, as it disrupts the binding of the catalytic subunit to regulatory B subunits, thereby altering phosphatase assembly and activity. Dysregulated PP2A activity, including aberrant Tyr307 phosphorylation, has been implicated in pathologies such as cancer, neurodegenerative disorders, and cardiovascular diseases. The PP2A-Cα (Phospho-Tyr307) antibody enables researchers to study the dynamic regulation of PP2A in response to cellular signals, such as growth factors or stress stimuli, by specifically recognizing the phosphorylated form of Tyr307. It is widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore PP2A’s role in health and disease, offering insights into mechanisms underlying cellular homeostasis and therapeutic targeting.