Rabbit Polyclonal Mcl-1(Phospho-Ser159) Antibody

The Mcl-1 (Phospho-Ser159) antibody is a specialized tool used to detect the phosphorylation status of the anti-apoptotic protein Mcl-1 (Myeloid cell leukemia-1) at serine residue 159. Mcl-1. a member of the Bcl-2 family, plays a critical role in regulating mitochondrial-dependent apoptosis by inhibiting pro-apoptotic proteins like Bax and Bak. Its expression is tightly controlled at transcriptional, translational, and post-translational levels, with phosphorylation being a key regulatory mechanism. Phosphorylation at Ser159. mediated by kinases such as GSK3β, has been linked to Mcl-1 destabilization and proteasomal degradation, promoting apoptosis under stress conditions. This site-specific phosphorylation often occurs in response to cellular signals or therapeutic agents, making it relevant in cancer research, particularly in studying drug resistance mechanisms. The Mcl-1 (Phospho-Ser159) antibody enables researchers to investigate this modification in experimental models, aiding studies on apoptosis regulation, cancer progression, and therapeutic targeting. Its specificity is validated through techniques like knockout controls or phosphatase treatment. Understanding Mcl-1 phosphorylation dynamics provides insights into cellular survival pathways and potential biomarkers for diseases like hematologic malignancies.