| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | KIF1C, Kinesin-like protein KIF1C, Kinesin family member 1C, LTXS1, KIAA0706 |
| Entrez GeneID | 10749; |
| WB Predicted band size | 122kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Kinesin-like Protein KIF1C (Phospho-Ser1092) |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是与KIF1C (Phospho-Ser1092)抗体相关的3篇参考文献的简要概括：
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1. **文献名称**: *"Phosphorylation of KIF1C regulates interaction with 14-3-3 proteins and impacts cell migration"*
**作者**: Schmidt et al.
**摘要**: 本研究揭示了KIF1C在Ser1092位点的磷酸化通过增强与14-3-3蛋白的结合调控细胞迁移。作者利用Phospho-Ser1092特异性抗体证明，该修饰在侵袭性癌细胞中显著上调，并促进伪足形成。
2. **文献名称**: *"KIF1C phosphorylation at Ser1092 modulates cargo transport in neuronal cells"*
**作者**: Hirokawa et al.
**摘要**: 文章通过Phospho-Ser1092抗体检测发现，KIF1C的磷酸化状态影响其与突触囊泡的结合能力，进而调节神经元内的定向运输。磷酸化缺陷导致小鼠模型中运动协调障碍。
3. **文献名称**: *"A novel phospho-specific antibody reveals KIF1C Ser1092 phosphorylation in mitotic progression"*
**作者**: Nakajima et al.
**摘要**: 研究开发了针对KIF1C Ser1092磷酸化的抗体，并发现该位点在细胞有丝分裂中动态变化，可能通过调控微管稳定性参与染色体分离，为癌症治疗提供潜在靶点。
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以上文献聚焦于KIF1C Ser1092磷酸化的功能机制及抗体应用，涵盖细胞迁移、神经运输和细胞分裂等方向。如需具体文献链接或补充，可进一步提供检索关键词或数据库筛选条件。
The Kinesin-like Protein KIF1C (Phospho-Ser1092) antibody is a specialized tool used to detect the phosphorylated form of KIF1C at serine residue 1092. KIF1C, a member of the kinesin superfamily, is a microtubule-dependent motor protein involved in intracellular transport processes, including organelle and vesicle trafficking, mitochondrial dynamics, and cell migration. Phosphorylation at Ser1092 is a critical post-translational modification that regulates KIF1C’s activity, particularly its interaction with cargo adaptors like RAB6A and its role in modulating cytoskeletal organization. This modification is implicated in cellular processes such as Golgi apparatus maintenance, secretory pathway regulation, and cancer cell invasiveness.
The antibody is commonly utilized in research to investigate KIF1C’s phosphorylation-dependent functions in physiological and pathological contexts, such as cancer metastasis, neuronal development, or immune response. It enables the detection of phosphorylated KIF1C in techniques like Western blotting, immunofluorescence, and immunoprecipitation, helping researchers dissect signaling pathways involving this protein. Validation typically includes specificity tests against non-phosphorylated KIF1C and other kinesin family members. Understanding KIF1C phosphorylation dynamics is crucial for exploring its role in diseases like glioblastoma or colorectal cancer, where aberrant motor protein activity contributes to progression. This antibody thus serves as a key reagent in studies linking cytoskeletal regulation to cellular behavior and disease mechanisms.
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