| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/300 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CALT; CEN2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CETN2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于Rabphilin 3A (phospho-Ser237)抗体的3篇参考文献(虚构示例，供参考)：
1. **文献名称**: "Rabphilin 3A phosphorylation at Ser237 regulates synaptic vesicle exocytosis"
**作者**: Smith A, et al.
**摘要**: 研究揭示了Ser237磷酸化通过调控Rabphilin 3A与Rab3的相互作用，影响突触小泡的胞吐过程，并开发了特异性抗体用于检测该位点的磷酸化状态。
2. **文献名称**: "Phosphorylation-dependent binding of Rabphilin 3A to calcium channels in neurons"
**作者**: Tanaka Y, et al.
**摘要**: 报道了Ser237磷酸化增强Rabphilin 3A与神经元电压门控钙通道的结合能力，使用phospho-Ser237抗体验证了其在神经活动中的动态修饰。
3. **文献名称**: "Altered Rabphilin 3A phosphorylation in a mouse model of epilepsy"
**作者**: Lee H, et al.
**摘要**: 通过phospho-Ser237抗体发现癫痫模型中Rabphilin 3A的异常磷酸化，提示其可能参与突触传递紊乱的病理机制。
(注：以上文献为模拟内容，实际研究中请通过PubMed或Google Scholar检索真实文献。)
Rabphilin 3A is a synaptic vesicle-associated protein that interacts with the small GTPase RAB3A, playing a role in regulating neurotransmitter release and synaptic plasticity. Its function is modulated by phosphorylation at specific residues, including serine 237 (Ser237). Phosphorylation at Ser237 is thought to influence Rabphilin 3A’s interactions with other synaptic proteins or its subcellular localization, potentially affecting vesicle docking, fusion, or recycling processes. The Rabphilin 3A (phospho-Ser237) antibody is a specialized tool designed to detect this post-translational modification, enabling researchers to study the protein’s activity-dependent regulation in neuronal signaling.
This antibody is commonly used in techniques like Western blotting, immunohistochemistry, or immunofluorescence to assess phosphorylation status in cellular or tissue samples. Its specificity for the phosphorylated form of Ser237 makes it valuable for investigating signaling pathways linked to synaptic activity, neurodevelopment, or neurological disorders. For example, altered Rabphilin 3A phosphorylation has been implicated in conditions affecting synaptic transmission, such as epilepsy or neurodegenerative diseases. Validation of the antibody typically involves knockout controls or peptide competition assays to confirm target specificity. Researchers in neuroscience, cell biology, or neuropharmacology may employ this reagent to explore molecular mechanisms underlying synaptic vesicle dynamics or to identify biomarkers for neurological dysfunction.
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