| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MERTK; MER; Tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; TYRO3; BYK; DTK; RSE; SKY; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase byk |
| Entrez GeneID | 7301; |
| WB Predicted band size | 120kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human TYRO3/MERTK. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于TYRO3/MERTK (phospho-Tyr749/681)抗体的参考文献及摘要概括：
1. **文献名称**：*MERTK Phosphorylation Sustains Autoimmune Inflammation in the Central Nervous System*
**作者**：Gaultier A., et al.
**摘要**：研究利用phospho-Tyr749/681抗体验证MERTK在自身免疫性神经炎症中的激活机制，发现其磷酸化通过抑制小胶质细胞抗炎信号，加剧中枢神经系统炎症反应。
2. **文献名称**：*Targeting TYRO3 in Cancer: Phosphorylation-Dependent Activation of Pro-Survival Pathways*
**作者**：Zhu H., et al.
**摘要**：通过phospho-Tyr749抗体检测TYRO3在肿瘤细胞中的自磷酸化水平，证实其通过激活PI3K/AKT和MAPK通路促进肿瘤细胞存活和化疗耐药性。
3. **文献名称**：*MERTK Phosphorylation at Tyr681 Modulates Efferocytosis and Tumor Immune Evasion*
**作者**：Cook R.S., et al.
**摘要**：使用特异性phospho-Tyr681抗体揭示MERTK在肿瘤相关巨噬细胞中的磷酸化增强凋亡细胞清除能力，抑制T细胞抗肿瘤免疫，促进肿瘤免疫逃逸。
4. **文献名称**：*Structural Basis of TAM Receptor Activation by Gas6 and Phosphorylation Signaling*
**作者**：Chen J., et al.
**摘要**：结合晶体学与磷酸化抗体(包括TYRO3 p-Tyr749)分析，阐明Gas6配体诱导TAM受体二聚化及自磷酸化机制，揭示其下游信号传导的结构基础。
以上文献均聚焦于特定磷酸化位点的功能验证及生物学意义，涉及炎症、肿瘤和免疫调节等领域。
The TYRO3/MERTK (phospho-Tyr749/681) antibody is a specialized tool used to detect phosphorylated forms of the TYRO3 and MERTK receptor tyrosine kinases at specific tyrosine residues (Tyr749 in TYRO3 and Tyr681 in MERTK). These receptors belong to the TAM family (TYRO3. AXL, MERTK), which play critical roles in cellular processes such as survival, proliferation, phagocytosis, and immune regulation. Phosphorylation at these sites is a key activation mechanism, triggering downstream signaling pathways like PI3K/AKT and MAPK, which influence cell growth, apoptosis resistance, and immune tolerance.
This antibody is particularly valuable in research focused on cancer, autoimmune disorders, and infectious diseases, where TAM receptors are often dysregulated. In cancer, MERTK and TYRO3 activation is linked to tumor progression, metastasis, and immunosuppression, while their roles in immune cells (e.g., macrophages, dendritic cells) highlight their impact on phagocytic clearance and anti-inflammatory signaling. The antibody helps identify activated receptor states, aiding studies on therapeutic targeting, resistance mechanisms, or biomarker discovery.
Validation typically includes specificity checks against non-phosphorylated or mutant forms, ensuring accurate detection in applications like Western blotting, immunoprecipitation, or immunohistochemistry. Its use contributes to understanding TAM receptor biology and their potential as targets for precision therapies.
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