| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ALEX1 |
| Entrez GeneID | 51309; |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein corresponding to residues near the C terminal of human armadillo repeat containing, X-linked 1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于ARMCX1抗体的参考文献(示例为虚构内容，实际文献需通过数据库检索获取)：
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1. **文献名称**: "ARMCX1 regulates mitochondrial transport and neuronal development"
**作者**: Li, X. et al.
**摘要**: 本研究利用ARMCX1特异性抗体进行免疫荧光和Western blot分析，发现ARMCX1蛋白在小鼠大脑皮层神经元中调控线粒体轴突运输，其缺失导致神经元突触发育异常。
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2. **文献名称**: "ARMCX1 expression in human cancers: A biomarker study"
**作者**: Garcia, R. et al.
**摘要**: 通过免疫组化(ARMCX1抗体：Abcam #ab12345)分析多种癌症组织样本，发现ARMCX1在胃癌中显著下调，并与患者预后不良相关，提示其可能的抑癌作用。
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3. **文献名称**: "Functional characterization of ARMCX1 in mitochondrial dynamics"
**作者**: Chen, L. et al.
**摘要**: 结合CRISPR/Cas9敲除技术和ARMCX1抗体验证，证明ARMCX1通过与微管结合蛋白相互作用调控线粒体形态，其缺失导致线粒体碎片化及细胞能量代谢障碍。
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4. **文献名称**: "ARMCX1 interacts with the MIEF1 protein to modulate mitochondrial distribution"
**作者**: Park, S. et al.
**摘要**: 使用ARMCX1抗体进行免疫共沉淀(Co-IP)和共聚焦显微镜观察，揭示ARMCX1与MIEF1形成复合物，共同调控线粒体在细胞内的空间定位。
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**备注**：以上文献为示例，实际引用时请通过PubMed、Google Scholar等平台以关键词“ARMCX1 antibody”或“ARMCX1 protein function”检索真实文献，并核对抗体货号、实验方法及结论。
The ARMCX1 antibody is a tool used to detect the ARMCX1 protein, a member of the ARMCX family located on the X chromosome. ARMCX1 (Armadillo repeat-containing X-linked protein 1) is encoded by the ARMCX1 gene and is implicated in mitochondrial dynamics and cellular trafficking, particularly in neurons. It contains Armadillo (ARM) repeat domains, which facilitate protein-protein interactions. While its exact biological role remains under investigation, studies suggest ARMCX1 may regulate mitochondrial transport or morphology, impacting cellular energy distribution and apoptosis.
ARMCX1 antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study protein expression, localization, and function. These antibodies help identify tissue-specific expression patterns, with higher levels observed in the brain, testis, and certain cancers. Researchers also employ ARMCX1 antibodies to explore its potential role in diseases, such as neurodevelopmental disorders or cancers, where dysregulated expression has been reported.
Specificity validation is critical, as ARMCX1 shares homology with other ARMCX family members (e.g., ARMCX2-6). Many commercial antibodies are validated using knockout cell lines or siRNA-mediated knockdown to confirm target specificity. Recent studies highlight ARMCX1's interaction with proteins involved in mitochondrial membrane organization, suggesting its involvement in cellular stress responses. Further research using these antibodies may clarify its mechanistic contributions to health and disease.
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