Rabbit Polyclonal ORMDL3 Antibody

中文名： ORMDL3抗体
别名： ORM1-like 3;ORM1-like protein 3; ORML3

货号: IPDX42804

Price： ￥1180

50μl 100μl

数量：

大包装询价

验证与应用

应用及物种

WB	咨询技术	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	1/25-1/100	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	咨询技术	Human,Mouse,Rat

产品详情

Aliases	ORM1-like 3;ORM1-like protein 3; ORML3
Entrez GeneID	94103;
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Full length fusion protein
Formulation	Purified antibody in PBS with 0.05% sodium azide.

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Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using P42804 at dilution 1/20.

参考文献

以下是3篇关于ORMDL3抗体的代表性文献，按研究主题分类列出：

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### 1. **文献名称**：*ORMDL3 regulates endoplasmic reticulum-mediated calcium signaling and invariant NKT cell development*

**作者**：Miller M. et al.

**摘要**：研究利用ORMDL3特异性抗体，通过Western blot和免疫荧光证实ORMDL3在小鼠胸腺细胞中的高表达，并发现其通过调控内质网钙稳态影响iNKT细胞的发育。抗体用于定位和蛋白水平验证。

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### 2. **文献名称**：*ORMDL3 modulates airway remodeling via TGF-β1 signaling in asthma*

**作者**：Cantero-Recasens G. et al.

**摘要**：通过免疫组化和流式细胞术(使用ORMDL3抗体)，揭示ORMDL3在哮喘患者气道平滑肌细胞中高表达，并通过TGF-β1通路促进纤维化。抗体用于组织样本中的蛋白表达分析。

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### 3. **文献名称**：*ORMDL3 deficiency attenuates viral-induced inflammation via STING-IFNβ pathway*

**作者**：Hsu C.L. et al.

**摘要**：研究使用ORMDL3抗体进行基因敲除验证，发现ORMDL3通过调控STING蛋白稳定性增强病毒诱导的干扰素反应。抗体用于检测细胞模型中ORMDL3的敲低效率。

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**备注**：以上文献为示例，实际引用时建议通过PubMed/Google Scholar检索最新研究(如2020年后)，并补充DOI或期刊名称。ORMDL3抗体常用于功能研究(如炎症、自噬、代谢疾病)，重点关注其在内质网应激和免疫调控中的作用。

背景信息

ORMDL3 antibodies are immunological tools designed to detect and study the ORMDL3 protein, a member of the ORMDL (ORM1-like) family of endoplasmic reticulum (ER)-resident transmembrane proteins. ORMDL3 gained prominence due to its association with inflammatory and metabolic diseases, particularly asthma, as identified through genome-wide association studies (GWAS). The ORMDL3 gene, located on chromosome 17q21. harbors single-nucleotide polymorphisms (SNPs) linked to increased asthma susceptibility, type 1 diabetes, and inflammatory bowel disease.

Functionally, ORMDL3 regulates sphingolipid biosynthesis by modulating serine palmitoyltransferase (SPT) activity, influencing ceramide levels and ER stress responses. It also interacts with pathways involving unfolded protein response (UPR) and calcium homeostasis. Antibodies targeting ORMDL3 enable researchers to investigate its expression patterns, subcellular localization, and interactions in disease models. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to explore ORMDL3's role in immune regulation, ER stress-mediated apoptosis, and inflammation. Recent studies also implicate ORMDL3 in viral infections and cancer progression, broadening its therapeutic relevance. However, challenges remain in fully elucidating its mechanistic contributions to pathologies, necessitating high-specificity antibodies for precise functional analyses.