| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RS; RGS; ARP1; Brx1; IDG2; IGDS; IHG2; PTX2; RIEG; IGDS2; IRID2; Otlx2; RIEG1 |
| Entrez GeneID | 5308; |
| WB Predicted band size | 35kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein corresponding to residues near the N terminal of human paired-like homeodomain 2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PITX2抗体的3篇文献摘要示例(虚构内容，供参考)：
1. **文献名称**: *PITX2 expression in atrial fibrillation: Immunohistochemical analysis*
**作者**: Smith A, et al.
**摘要**: 研究使用PITX2抗体通过免疫组化技术分析房颤患者心脏组织中PITX2蛋白的表达水平，发现其表达降低与心律失常发生相关。
2. **文献名称**: *Role of PITX2 in left-right asymmetry: Antibody validation in mouse models*
**作者**: Chen L, et al.
**摘要**: 通过Western blot和免疫荧光技术验证PITX2抗体的特异性，并揭示PITX2在小鼠胚胎左右不对称发育中的调控机制。
3. **文献名称**: *PITX2 as a biomarker in prostate cancer: A comparative study*
**作者**: Gupta R, et al.
**摘要**: 利用PITX2抗体检测前列腺癌组织样本，发现其高表达与肿瘤侵袭性相关，提示其作为潜在诊断标志物的价值。
(注：以上文献为示例，实际引用需通过PubMed等数据库检索真实发表的研究。)
The PITX2 antibody is a crucial tool for studying the PITX2 (Paired-like homeodomain transcription factor 2) protein, a key regulator in embryonic development and disease. PITX2. a member of the homeodomain transcription factor family, plays essential roles in organogenesis, particularly in heart, ocular, and dental development, as well as left-right asymmetry patterning. It is encoded by the PITX2 gene, located on human chromosome 4q25. and mutations in this gene are linked to Axenfeld-Rieger syndrome, a disorder affecting eye, tooth, and umbilical development.
PITX2 antibodies are widely used to detect and quantify PITX2 isoforms (PITX2A, PITX2B, PITX2C) in Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate PITX2's role in cellular differentiation, cell cycle regulation, and its interaction with signaling pathways like Wnt/β-catenin. Dysregulation of PITX2 is implicated in cancers (e.g., prostate, colorectal) and cardiac defects, making its antibody valuable for diagnostic and mechanistic studies. Researchers prioritize antibodies validated for specificity, often confirmed via knockout controls or peptide blocking assays. Host species (rabbit, mouse) and clonality (monoclonal/polyclonal) are selected based on experimental needs. Its applications span developmental biology, oncology, and regenerative medicine research.
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