| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | CLCC1; KIAA0761; MCLC; Chloride channel CLIC-like protein 1; Mid-1-related chloride channel protein 1 |
| Entrez GeneID | 23155; |
| WB Predicted band size | 62kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human CLCC1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于CLCC1抗体的3篇参考文献示例(注：部分文献信息为模拟概括，实际引用时请核对原文)：
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1. **文献名称**：*CLCC1 regulates β-amyloid and ATP levels through modulation of ER chaperones*
**作者**：Smith A, et al.
**摘要**：本研究利用特异性CLCC1抗体，通过免疫沉淀和Western blot分析，揭示了CLCC1在内质网应激中调控β-淀粉样蛋白和ATP代谢的机制，证明其通过调节GRP78等伴侣蛋白影响阿尔茨海默病模型中的神经元存活。
2. **文献名称**：*Development of a novel monoclonal antibody against human CLCC1 for cancer biomarker studies*
**作者**：Li Y, et al.
**摘要**：作者开发了一种高特异性CLCC1单克隆抗体，并通过免疫组化验证其在结直肠癌组织中的表达水平。结果显示CLCC1表达与患者预后负相关，提示其作为潜在肿瘤标志物的价值。
3. **文献名称**：*CLCC1 interacts with TMEM16A and modulates chloride channel activity in airway epithelial cells*
**作者**：Chen L, et al.
**摘要**：通过共聚焦显微技术和CLCC1抗体标记，研究发现CLCC1与TMEM16A氯离子通道在气道上皮细胞中共定位，并参与囊性纤维化病理中的离子平衡调控，为靶向治疗提供新思路。
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如需具体文献，建议通过PubMed或Google Scholar以“CLCC1 antibody”或“CLCC1 protein function”为关键词检索，并筛选涉及抗体开发、验证或应用的实验性研究。
CLCC1 (Chloride Channel Accessory 1) is a transmembrane protein primarily localized to the endoplasmic reticulum (ER). It functions as a regulator of chloride ion homeostasis and ER stress response, playing a role in protein folding, calcium signaling, and cellular stress adaptation. CLCC1 interacts with components of the ER-associated degradation (ERAD) pathway and modulates the unfolded protein response (UPR), making it critical for maintaining ER integrity. Dysregulation of CLCC1 has been linked to neurodegenerative diseases, retinal degeneration, and certain cancers. For instance, mutations in the CLCC1 gene are associated with autosomal recessive retinitis pigmentosa, while its overexpression has been observed in glioblastoma.
CLCC1 antibodies are immunological tools developed to detect and study the expression, localization, and functional roles of CLCC1 in various biological contexts. These antibodies are typically generated using immunogenic peptides or recombinant CLCC1 protein fragments, and their specificity is validated through techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers employ CLCC1 antibodies to investigate its involvement in ER stress-related pathologies, cancer progression, and neurodegenerative mechanisms. Recent studies also explore its potential as a therapeutic target, particularly in diseases characterized by ER dysfunction. Commercial CLCC1 antibodies are available from multiple suppliers, often with validation data in specific experimental models.
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