| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000 | Human,Mouse,Rat |
| Aliases | CYP2S1; Cytochrome P450 2S1; CYPIIS1 |
| Entrez GeneID | 29785; |
| WB Predicted band size | 56kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from the Internal region of human CYP2S1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于CYP2S1抗体的3篇参考文献的简要整理(注：文献信息为模拟示例，若需真实文献请通过学术数据库检索)：
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1. **文献名称**：*"Characterization of a polyclonal antibody against human CYP2S1 for detection in hepatic and extrahepatic tissues"*
**作者**：Smith A, et al.
**摘要**：研究开发了一种针对人CYP2S1的多克隆抗体，并通过免疫组化和Western blot验证其特异性。结果显示CYP2S1在肝、肺和肠道组织中广泛表达，提示其在异生物质代谢中的潜在作用。
2. **文献名称**：*"CYP2S1 expression in human tumors: An immunohistochemical study using a novel monoclonal antibody"*
**作者**：Jones R, et al.
**摘要**：利用新型单克隆抗体分析CYP2S1在多种肿瘤中的表达。结果显示，CYP2S1在结直肠癌和肺癌中显著上调，可能与肿瘤微环境中的氧化应激反应相关。
3. **文献名称**：*"Functional role of CYP2S1 in keratinocytes revealed by antibody-mediated inhibition studies"*
**作者**：Wang L, et al.
**摘要**：通过特异性抗体阻断CYP2S1的活性，研究其在皮肤角质细胞中的功能。实验表明，CYP2S1参与紫外线诱导的视黄酸代谢，影响细胞增殖和炎症反应。
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如需具体文献，建议在PubMed或Google Scholar中检索关键词“CYP2S1 antibody”或结合研究主题筛选近期论文。
CYP2S1. a member of the cytochrome P450 enzyme family, is involved in the metabolism of endogenous and exogenous compounds, including drugs, environmental toxins, and signaling molecules. It is expressed in epithelial tissues, such as the skin, lungs, and gastrointestinal tract, and has been implicated in cancer progression, inflammatory responses, and detoxification pathways. Antibodies targeting CYP2S1 are critical tools for studying its expression, localization, and functional roles in both physiological and pathological contexts.
Polyclonal and monoclonal CYP2S1 antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence to assess protein levels in tissue samples or cell lines. Research has shown that CYP2S1 is overexpressed in certain cancers (e.g., colorectal, breast, and lung tumors), suggesting its potential as a biomarker or therapeutic target. Conversely, reduced expression has been linked to inflammatory skin disorders or impaired detoxification.
Despite its significance, CYP2S1's substrate specificity and regulatory mechanisms remain incompletely understood. Antibody-based studies continue to clarify its interactions with metabolites, signaling pathways, and disease mechanisms. Challenges include ensuring antibody specificity due to structural similarities among P450 isoforms. Ongoing efforts aim to optimize antibody validation protocols (e.g., knockout controls) to enhance reproducibility in research. These advancements could drive translational applications, such as personalized medicine or targeted therapies modulating CYP2S1 activity.
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