WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 咨询技术 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 1/10000 | Human,Mouse,Rat |
Aliases | DNAJC5; CSP; DnaJ homolog subfamily C member 5; Cysteine string protein; CSP |
Entrez GeneID | 80331; |
WB Predicted band size | 30kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Mouse,Rat |
Immunogen | Synthesized peptide derived from the C-terminal region of human CSP. |
Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇关于环子孢子蛋白(CSP)抗体的代表性文献摘要(示例仅供参考,具体文献请通过学术数据库核实):
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1. **文献名称**:*Structural basis for antibody recognition of the NANP-repeat epitope of Plasmodium falciparum circumsporozoite protein*
**作者**:Kisalu, N.K. et al.
**摘要**:该研究通过冷冻电镜解析了单克隆抗体CIS43与疟原虫CSP蛋白NANP重复表位结合的分子机制,揭示了抗体如何中和疟原虫子孢子入侵肝细胞的关键结构基础,为疫苗设计提供指导。
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2. **文献名称**:*A human monoclonal antibody prevents malaria infection by targeting a conserved site on the circumsporozoite protein*
**作者**:Tan, J. et al.
**摘要**:报道了一种人源单克隆抗体(mAb L9),其通过靶向CSP的保守区域阻断疟原虫感染。动物实验表明,L9可完全抑制疟原虫子孢子移动和肝细胞入侵,提示其作为预防性治疗的潜力。
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3. **文献名称**:*RTS,S/AS01 malaria vaccine induces memory and polyfunctional T cell responses in a pediatric African phase III trial*
**作者**:Olotu, A. et al.
**摘要**:针对RTS,S疫苗(基于CSP抗原)的III期临床试验,分析了接种后儿童体内CSP特异性抗体水平及T细胞免疫反应,证实高抗体滴度与疟疾保护率呈正相关,但保护效果随接种时间递减。
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**备注**:以上文献标题和内容为示例性质,具体研究请通过PubMed、Google Scholar等平台以关键词“CSP antibody”、“circumsporozoite protein malaria”检索近年或经典论文。
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