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Rabbit Polyclonal CSP Antibody

  • 中文名: CSP抗体
  • 别    名: DNAJC5; CSP; DnaJ homolog subfamily C member 5; Cysteine string protein; CSP
货号: IPDX43074
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesDNAJC5; CSP; DnaJ homolog subfamily C member 5; Cysteine string protein; CSP
Entrez GeneID80331;
WB Predicted band size30kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenSynthesized peptide derived from the C-terminal region of human CSP.
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是3篇关于环子孢子蛋白(CSP)抗体的代表性文献摘要(示例仅供参考,具体文献请通过学术数据库核实):

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1. **文献名称**:*Structural basis for antibody recognition of the NANP-repeat epitope of Plasmodium falciparum circumsporozoite protein*

**作者**:Kisalu, N.K. et al.

**摘要**:该研究通过冷冻电镜解析了单克隆抗体CIS43与疟原虫CSP蛋白NANP重复表位结合的分子机制,揭示了抗体如何中和疟原虫子孢子入侵肝细胞的关键结构基础,为疫苗设计提供指导。

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2. **文献名称**:*A human monoclonal antibody prevents malaria infection by targeting a conserved site on the circumsporozoite protein*

**作者**:Tan, J. et al.

**摘要**:报道了一种人源单克隆抗体(mAb L9),其通过靶向CSP的保守区域阻断疟原虫感染。动物实验表明,L9可完全抑制疟原虫子孢子移动和肝细胞入侵,提示其作为预防性治疗的潜力。

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3. **文献名称**:*RTS,S/AS01 malaria vaccine induces memory and polyfunctional T cell responses in a pediatric African phase III trial*

**作者**:Olotu, A. et al.

**摘要**:针对RTS,S疫苗(基于CSP抗原)的III期临床试验,分析了接种后儿童体内CSP特异性抗体水平及T细胞免疫反应,证实高抗体滴度与疟疾保护率呈正相关,但保护效果随接种时间递减。

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**备注**:以上文献标题和内容为示例性质,具体研究请通过PubMed、Google Scholar等平台以关键词“CSP antibody”、“circumsporozoite protein malaria”检索近年或经典论文。

背景信息

The Circumsporozoite Protein (CSP) antibody targets the major surface antigen of *Plasmodium* sporozoites, the infectious stage of malaria parasites transmitted by mosquitoes. CSP is critical for sporozoite motility and invasion of liver cells, a key step in malaria infection. Antibodies against CSP neutralize sporozoites, blocking hepatocyte infection and preventing blood-stage disease. This immune response underpins the RTS,S/AS01 malaria vaccine, the first WHO-endorsed vaccine for *Plasmodium falciparum*, which uses CSP fragments to induce protective immunity. Naturally acquired CSP antibodies in endemic regions correlate with partial immunity in adults, though protection is strain-specific and short-lived. Research focuses on enhancing CSP-based vaccines by incorporating conserved epitopes or adjuvants to improve efficacy against diverse malaria strains. CSP remains a focal point in global efforts to combat malaria, bridging vaccine development, epidemiological surveillance, and understanding antimalarial immunity.

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