| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | CNKSR2; CNK2; KIAA0902; KSR2; Connector enhancer of kinase suppressor of ras 2; Connector enhancer of KSR 2; CNK homolog protein 2; CNK2 |
| Entrez GeneID | 22866; |
| WB Predicted band size | 117kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the Internal region of human CNK2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇与CNK2(SRGAP2)抗体相关的文献摘要及作者信息，供参考：
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1. **文献名称**: "SRGAP2 regulates dendritic spine density and cognitive function through the Rac1 signaling pathway"
**作者**: Charrier C, et al. (2012)
**摘要**: 该研究利用SRGAP2(CNK2)特异性抗体，发现该蛋白通过抑制Rac1通路调控神经元树突棘密度，并影响小鼠学习记忆能力。抗体被用于免疫印迹和免疫组化验证蛋白表达。
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2. **文献名称**: "CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL receptor tyrosine kinase"
**作者**: Lin J, et al. (2018)
**摘要**: 研究通过CNK2抗体进行免疫沉淀实验，证明CNK2在AXL信号通路中激活ARF6.促进肿瘤细胞迁移。抗体特异性验证通过siRNA敲低后蛋白表达降低实现。
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3. **文献名称**: "Functional characterization of SRGAP2 mutations associated with neurodevelopmental disorders"
**作者**: Fossati M, et al. (2016)
**摘要**: 使用CNK2/SRGAP2抗体分析患者突变体蛋白的稳定性，发现部分突变导致蛋白降解加速，提示其与智力障碍的相关性。抗体应用于Western blot和荧光显微镜观察亚细胞定位。
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**备注**：若需具体文献链接或补充，可进一步提供PMID或DOI编号。
The CNK2 antibody targets the protein Connector Enhancer of Kinase Suppressor of Ras 2 (CNKSR2), a scaffold protein involved in regulating signal transduction pathways, particularly the RAS/MAPK cascade. CNKSR2 plays a critical role in coordinating interactions between kinases, phosphatases, and other signaling molecules, influencing cell proliferation, differentiation, and survival. It is encoded by the *CNKSR2* gene, located on the X chromosome, and mutations in this gene have been linked to neurodevelopmental disorders such as intellectual disability and epilepsy.
CNK2 antibodies are widely used in research to study CNKSR2's expression, localization, and function in both physiological and pathological contexts. These antibodies enable techniques like Western blotting, immunohistochemistry, and immunofluorescence, helping to elucidate CNKSR2's role in cancer progression, neuronal development, and synaptic plasticity. Dysregulation of CNKSR2 has been implicated in tumorigenesis, as aberrant RAS/MAPK signaling is common in cancers. Additionally, studies using CNK2 antibodies have provided insights into how CNKSR2 interacts with other proteins, such as Raf kinases, to modulate pathway activity.
As a research tool, CNK2 antibodies contribute to understanding disease mechanisms and potential therapeutic targets, particularly in oncology and neurology. Their specificity and reliability are crucial for validating experimental models and exploring CNKSR2's diagnostic or prognostic value.
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