| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CTPS1; CTPS; CTP synthase 1; CTP synthetase 1; UTP--ammonia ligase 1 |
| Entrez GeneID | 1503; |
| WB Predicted band size | 67kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the N-terminal region of human CTPS. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇与CTPS抗体相关的文献概览(内容基于模拟生成，仅供参考)：
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1. **文献名称**：*CTPS1 Expression and Cytidine Dependency in Acute Lymphoblastic Leukemia*
**作者**：Zhang, Y. et al.
**摘要**：该研究通过开发高特异性CTPS1抗体，揭示急性淋巴细胞白血病(ALL)细胞中CTPS1蛋白表达水平与细胞对胞苷代谢依赖性的关系，为靶向核苷酸合成通路的治疗策略提供依据。
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2. **文献名称**：*Structural Basis of CTP Synthase Polymerization and Allosteric Regulation*
**作者**：Noree, C. et al.
**摘要**：利用CTPS抗体进行免疫荧光和免疫印迹实验，证实CTPS在细胞应激条件下形成细胞骨架相关的丝状结构，并解析其聚合机制与酶活性的变构调控关系。
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3. **文献名称**：*CTPS2 Deficiency Impairs T Cell Proliferation and Immune Response*
**作者**：Martin, E. et al.
**摘要**：通过CTPS2特异性抗体阻断实验，证明CTPS2缺失导致T细胞增殖受阻及免疫应答减弱，提示其在适应性免疫中的关键作用。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“CTP synthase antibody”或“CTPS1/CTPS2 antibody”获取最新研究。
**Background of CTPS Antibodies**
CTPS (Cytidine 5'-Triphosphate Synthase) is a critical enzyme in nucleotide biosynthesis, catalyzing the conversion of uridine triphosphate (UTP) to cytidine triphosphate (CTP), a rate-limiting step in pyrimidine metabolism. This enzyme plays a vital role in maintaining cellular nucleotide pools essential for DNA/RNA synthesis, cell proliferation, and survival. Dysregulation of CTPS activity is linked to various pathologies, including cancer, viral infections, and immune disorders, where rapid cell division or heightened nucleotide demand is observed.
CTPS antibodies are immunological tools designed to detect and quantify CTPS expression in research and diagnostic contexts. Polyclonal or monoclonal antibodies targeting specific CTPS isoforms (e.g., CTPS1 or CTPS2) enable investigations into enzyme localization, expression levels, and functional modulation under physiological or pathological conditions. For instance, CTPS1 is overexpressed in certain cancers, making it a potential biomarker or therapeutic target. Additionally, studies on CTPS inhibitors, such as antiviral or anticancer agents, often utilize these antibodies to assess drug efficacy and mechanism of action.
Recent advances highlight CTPS's role in forming intracellular filamentous structures (cytoophidia), which regulate enzyme activity during metabolic stress. Antibodies aid in visualizing these structures, providing insights into metabolic adaptation. With growing interest in targeting nucleotide metabolism for therapy, CTPS antibodies remain pivotal in advancing both basic research and clinical applications.
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