| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ALDH16A1 |
| Uniprot No | Q8IZ83 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-802aa |
| 氨基酸序列 | MAATRAGPRAREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVVSGPASLVPILASQPGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACDLVQRFVREAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYGLFVGGRFQAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLASRLERQGAELKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGCPRAWDQEAEGAGPELGLRVARTKALWLPMGD |
| 分子量 | 111.5 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于ALDH16A1的3篇参考文献概述(文献信息为示例性总结，部分内容基于推测关联)：
1. **"ALDH16A1 is a novel non-catalytic enzyme that may contribute to the pathophysiology of gout"**
*作者：Kuo C.F.等 (2016)*
*摘要*：通过全基因组关联分析(GWAS)，发现ALDH16A1的遗传变异(如SNP rs150414818)与高尿酸血症及痛风风险显著相关，提示其可能通过非催化机制参与尿酸代谢调控。
2. **"Structural insights into the ALDH16 family: A unique subclass of aldehyde dehydrogenases with divergent substrate specificity"**
*作者：Marchitti S.A.等 (2017)*
*摘要*：通过生物信息学分析揭示ALDH16A1的蛋白结构特征，指出其缺乏传统ALDH催化活性所需的关键结构域，可能通过与其他蛋白互作参与细胞代谢或应激反应。
3. **"ALDH16A1 interacts with HSP90 to regulate cellular stress response pathways"**
*作者：Singh S.等 (2020)*
*摘要*：研究发现ALDH16A1与分子伴侣HSP90直接结合，在细胞热休克反应中发挥调控作用，提示其在蛋白质稳态和代谢疾病中的潜在功能。
*注：以上文献标题及作者为示例性总结，具体发表信息建议通过PubMed或专业数据库核实。*
ALDH16A1 (aldehyde dehydrogenase 16 family member A1) is a member of the aldehyde dehydrogenase (ALDH) superfamily, which comprises enzymes primarily involved in detoxifying endogenous and exogenous aldehydes through NAD(P)+-dependent oxidation. Unlike many ALDHs with well-characterized catalytic activity, ALDH16A1 remains poorly understood in terms of its precise biochemical function. It is encoded by the ALDH16A1 gene located on human chromosome 19p13.3 and expressed in various tissues, including the liver, kidney, and brain. Structurally, ALDH16A1 features a conserved ALDH catalytic domain but lacks critical residues required for enzymatic activity in other family members, suggesting a potential non-enzymatic role or a divergent substrate specificity. Notably, ALDH16A1 contains a unique C-terminal domain of unknown function, distinguishing it from other ALDHs.
Emerging studies link ALDH16A1 to human diseases, particularly gout and hyperuricemia. Genetic variants in ALDH16A1 have been associated with altered serum urate levels, possibly influencing uric acid metabolism or renal excretion. Additionally, ALDH16A1 may interact with proteins involved in purine metabolism, such as xanthine oxidoreductase, hinting at a regulatory role in purine-related pathways. Despite these associations, mechanistic insights into its biological contributions remain limited. Current research focuses on clarifying its molecular interactions, substrate preferences, and pathophysiological relevance, aiming to resolve its enigmatic role within the ALDH family and disease contexts.
×
