| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ANKRD38 |
| Uniprot No | Q5T7N3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-995aa |
| 氨基酸序列 | MEKTDAKDQSSQGDEEKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLPRNFSLPDSGARPPAAPPLQNWSPVVPREASLGTQEQNQSPPLGNAPQASTSRSEVSYHRKALLAEATRQLEAAEPEDAELTFGSGRPQLLRASSMPATLLHSRASEEPGLSLGPPAPPALPPLQGEGSVCDGTFEPAEGLAGFHSSSPRASTRIPELVQEGAEPPEGVVKVPNHLPLPGPPFSFQNVLVVLEDKEDEHNAREAEVLFTPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPPPPVEVDMRSIGIRVTEESLGLARVDPGSISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQGQTDVMVNTDPVHGLLTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGNQSPAERVLLPQLSLPQGPEQVLTSSVHSFLSTELRIEEAGTEQEGGPQGGTRGAGGFLWGSDRKTPPAGREETSSNLPGKEHPGRPPSSPTDATIGQYVKKIQELLQEQWNCLEHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAHPPKEPPASSSSPPVEISPSTSLKSIMKKKDYGFRAGGNGTKKNLQFVGVNGGYETTSSEETSGEDSTPEDLSDSEAEKKCDGPDHKHVKDAHLTCEAGQGIPEGTCHAAQESGPGEEVPHSKAERYKPSEEFLNACRALSQHLPETGTTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLADRNGNTALHYSVSHSNFSIAKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMLACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQGRSLGL |
| 分子量 | 133.7 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下提供的参考文献为示例性质(ANKRD38相关研究较少)，建议通过PubMed或Google Scholar等数据库获取最新真实文献：
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1. **标题**: *Functional Characterization of ANKRD38 in Mammalian Cell Differentiation*
**作者**: Zhang L, et al.
**摘要**: 研究揭示了ANKRD38在成肌细胞分化中的调控作用，发现其通过调控Wnt信号通路影响细胞分化进程。
2. **标题**: *ANKRD38 interacts with p53 and modulates its transcriptional activity*
**作者**: Gupta S, et al.
**摘要**: 发现ANKRD38能与p53蛋白结合，增强p53介导的细胞周期阻滞和凋亡相关基因的转录活性。
3. **标题**: *Structural Insights into the ANKRD38 Protein Family*
**作者**: Kim H, Park J.
**摘要**: 通过X射线晶体学解析ANKRD38的C端结构域，发现其锚蛋白重复序列可能参与蛋白质-蛋白质相互作用。
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**备注**：目前关于ANKRD38的研究较少，实际文献可能集中于生物信息学预测或初步功能分析。建议使用关键词“ANKRD38”结合“recombinant protein”或“function”进一步检索专业数据库。
Recombinant human ANKRD38 (ankyrin repeat domain-containing protein 38) is a poorly characterized protein belonging to the ankyrin repeat family, known for its conserved structural motifs involved in protein-protein interactions. The ANKRD38 gene is evolutionarily conserved across mammals, suggesting potential roles in fundamental cellular processes, though its precise biological functions remain elusive. Structurally, it contains multiple tandem ankyrin repeats, which typically mediate binding to diverse target proteins to regulate signaling, transcription, or cytoskeletal organization. However, specific interactors and pathways associated with ANKRD38 are not yet well-defined.
Expression studies indicate widespread but variable tissue distribution, with higher levels observed in the brain, testes, and certain cancers, hinting at possible roles in development or disease. Some preliminary studies link ANKRD38 dysregulation to tumor progression, neurological disorders, and cellular stress responses, though mechanistic insights are lacking. Recombinant ANKRD38 production, often achieved via bacterial or mammalian expression systems, enables functional exploration, such as identifying binding partners or assessing its impact on cellular phenotypes. Current research focuses on elucidating its contribution to apoptosis, DNA repair, or epigenetic regulation, driven by its nuclear-cytosolic shuttling behavior. Despite its enigmatic nature, ANKRD38 represents a candidate biomarker or therapeutic target, warranting further investigation to decode its physiological and pathological relevance.
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