| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ANKRD40 |
| Uniprot No | Q6AI12 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-368aa |
| 氨基酸序列 | MNALLEQKEQQERLREAAALGDIREVQKLVESGVDVNSQNEVNGWTCLHWACKRNHGQVVSYLLKSGADKEILTTKGEMPVQLTSRREIRKIMGVEEEDDDDDDDDNLPQLKKESELPFVPNYLANPAFPFIYTPTAEDSAQMQNGGPSTPPASPPADGSPPLLPPGEPPLLGTFPRDHTSLALVQNGDVSAPSAILRTPESTKPGPVCQPPVSQSRSLFSSVPSKPPMSLEPQNGTYAGPAPAFQPFFFTGAFPFNMQELVLKVRIQNPSLRENDFIEIELDRQELTYQELLRVCCCELGVNPDQVEKIRKLPNTLLRKDKDVARLQDFQELELVLMISENNFLFRNAASTLTERPCYNRRASKLTY |
| 分子量 | 67.5 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是根据现有知识模拟生成的3篇关于ANKRD40的参考文献概要(非真实存在，仅供示例)：
1. **标题**：ANKRD40 regulates spermatogenesis through interaction with heat shock proteins
**作者**：Liu, X.; Chen, R. et al.
**摘要**：研究发现ANKRD40在睾丸组织中特异性高表达，通过与HSP70家族蛋白互作参与精子形成阶段的蛋白质折叠调控，基因敲除模型显示雄性小鼠生育力下降。
2. **标题**：Epigenetic silencing of ANKRD40 promotes tumor metastasis in colorectal cancer
**作者**：Wang, Y.; Zhang, H. et al.
**摘要**：揭示了结直肠癌中ANKRD40启动子区异常高甲基化导致其表达下调，进而通过WNT/β-catenin信号通路促进上皮间质转化(EMT)，临床数据分析显示低表达与患者生存率降低相关。
3. **标题**：ANKRD40 modulates neuronal differentiation via JNK signaling pathway
**作者**：Kim, S.; Park, J.H. et al.
**摘要**：体外实验表明，ANKRD40在神经干细胞中调控JNK磷酸化水平，影响神经元突触形成和树突复杂性，提示其在神经系统发育中的潜在作用。
建议通过PubMed、Web of Science等平台以“ANKRD40”为关键词检索最新真实文献。
**Background of ANKRD40 (Ankyrin Repeat Domain-Containing Protein 40)**
ANKRD40 is a protein encoded by the *ANKRD40* gene, characterized by the presence of multiple ankyrin repeat domains—structural motifs known to mediate protein-protein interactions. Although its precise biological functions remain incompletely understood, ANKRD40 has been implicated in diverse cellular processes, including transcriptional regulation, signal transduction, and stress response modulation. Studies suggest its potential involvement in regulating gene expression, particularly in response to DNA damage or cellular stress.
Emerging evidence links ANKRD40 to cancer progression, with altered expression observed in prostate, breast, and colorectal cancers, though its role as oncogenic or tumor-suppressive appears context-dependent. Additionally, ANKRD40 is associated with neurological conditions such as Alzheimer’s disease, where it may influence neuronal survival and inflammatory pathways.
Structurally, ANKRD40 contains a conserved N-terminal region with ankyrin repeats and a variable C-terminal domain, potentially enabling interactions with diverse molecular partners. Its expression is regulated by cellular stressors, including oxidative stress and cytokines, hinting at roles in adaptive cellular responses. Post-translational modifications, such as phosphorylation, may further modulate its activity.
Despite progress, ANKRD40’s exact mechanisms and physiological relevance remain understudied. Ongoing research aims to elucidate its molecular interactions, regulatory networks, and therapeutic potential in disease contexts.
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