| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ANKRD49 |
| Uniprot No | Q8WVL7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-239aa |
| 氨基酸序列 | MEKEKGNDDG IPDQENSLDF SEHFNQLELL ETHGHLIPTG TQSLWVGNSD EDEEQDDKNE EWYRLQEKKM EKDPSRLLLW AAEKNRLTTV RRLLSEKATH VNTRDEDEYT PLHRAAYSGH LDIVQELIAQ GADVHAVTVD GWTPLHSACK WNNTRVASFL LQHDADINAQ TKGLLTPLHL AAGNRDSKDT LELLLMNRYV KPGLKNNLEE TAFDIARRTS IYHYLFEIVE GCTNSSPQS |
| 分子量 | 53.7 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于ANKRD49的模拟参考文献及摘要(注：文献为假设性示例，实际研究中请核实真实来源)：
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1. **标题**: *ANKRD49 Promotes Lung Cancer Progression via Regulating NF-κB Signaling*
**作者**: Zhang L, Wang Y, Chen H
**摘要**: 研究发现ANKRD49在非小细胞肺癌组织中高表达，通过激活NF-κB信号通路增强癌细胞增殖和侵袭，沉默ANKRD49可抑制肿瘤生长并增加化疗敏感性。
2. **标题**: *ANKRD49 Interacts with DNA-PKcs to Facilitate DNA Damage Repair*
**作者**: Li X, Liu Q, Zhou R
**摘要**: 本文揭示ANKRD49与DNA依赖蛋白激酶催化亚基(DNA-PKcs)直接相互作用，促进电离辐射后的DNA双链断裂修复，表明其在基因组稳定性维持中的关键作用。
3. **标题**: *ANKRD49 Modulates Stem Cell Pluripotency through Wnt/β-Catenin Pathway*
**作者**: Kim S, Park J, Lee M
**摘要**: 研究证实ANKRD49在胚胎干细胞中高表达，通过调控Wnt/β-catenin通路维持干细胞多能性，抑制其表达会导致分化相关基因异常激活。
4. **标题**: *ANKRD49 Acts as a Novel Regulator of Apoptosis in Gastric Cancer*
**作者**: Wang T, Xu F, Gao X
**摘要**: ANKRD49通过抑制线粒体凋亡通路(如降低Bax/Bcl-2比值)拮抗胃癌细胞凋亡，其表达水平与患者预后不良显著相关。
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**提示**：若需真实文献，建议通过PubMed、Google Scholar等平台以“ANKRD49”或“ANKRD49 function”为关键词检索近期研究。
Ankyrin repeat domain-containing protein 49 (ANKRD49) is a member of the ankyrin repeat protein family, characterized by conserved structural motifs known as ankyrin repeats. These repeats facilitate protein-protein interactions, enabling ANKRD49 to participate in diverse cellular processes. While its precise molecular mechanisms remain under investigation, ANKRD49 has been implicated in DNA damage repair and genomic stability maintenance. Studies suggest it interacts with components of the DNA repair machinery, potentially acting as a regulatory scaffold or signaling mediator.
ANKRD49 expression is detected in multiple tissues, with elevated levels observed in testis, hinting at a possible role in germ cell development or meiosis. It has also been linked to cancer progression, where aberrant expression may influence tumor cell survival, proliferation, or chemotherapy resistance. For instance, ANKRD49 upregulation in lung adenocarcinoma correlates with poor patient prognosis, possibly through pathways involving NF-κB or p53 signaling.
Despite these associations, ANKRD49’s exact physiological functions and substrates remain elusive. Current research focuses on elucidating its interactome, post-translational modifications, and context-dependent roles in cellular stress responses. Its conserved ankyrin repeat domains and tissue-specific expression patterns make ANKRD49 a compelling target for understanding diseases linked to genomic instability or dysregulated protein interactions. Further studies are needed to define its therapeutic potential as a biomarker or intervention target.
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