| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ANXA2R |
| Uniprot No | Q3ZCQ2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-193aa |
| 氨基酸序列 | MEQHFLGCVK RAWDSAEVAP EPQPPPIVSS EDRGPWPLPL YPVLGEYSLD SCDLGLLSSP CWRLPGVYWQ NGLSPGVQST LEPSTAKPTE FSWPGTQKQQ EAPVEEVGQA EEPDRLRLQQ LPWSSPLHPW DRQQDTEVCD SGCLLERRHP PALQPWRHLP GFSDCLEWIL RVGFAAFSVL WACCSRICGA KQP |
| 分子量 | 21.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇与ANXA2R相关的文献摘要信息：
1. **《Annexin A2 receptor autoantibodies in thrombosis》**
*作者：Ling Q et al. (2022)*
摘要：研究揭示了抗ANXA2R自身抗体通过结合血管内皮细胞上的ANXA2R，促进血小板活化和血栓形成，提示其在血栓性疾病中的病理作用。
2. **《Structural basis of Annexin A2 receptor-mediated plasminogen activation》**
*作者：Wang Y et al. (2021)*
摘要：通过冷冻电镜解析ANXA2R与纤溶酶原复合物的三维结构，阐明其促进纤维蛋白降解的分子机制，为抗凝治疗提供新靶点。
3. **《ANXA2R as a coordinator of exosome biogenesis in cancer metastasis》**
*作者：Singh A et al. (2020)*
摘要：发现肿瘤细胞中ANXA2R通过调控外泌体分泌介导肿瘤微环境重塑，促进乳腺癌骨转移进程。
4. **《ANXA2R facilitates viral entry by bridging viruses and host cell membrane》**
*作者：Zhang L et al. (2019)*
摘要：证实ANXA2R作为肠道病毒EV71和SARS-CoV-2的共受体，通过其N端结构域介导病毒内吞作用，提示其作为抗病毒靶点潜力。
*注：上述文献为虚拟示例，实际引用需核实真实文献及DOI。*
Annexin A2 receptor (ANXA2R), primarily associated with the Annexin A2 (ANXA2) protein, functions as a co-receptor in various cellular processes. ANXA2. a calcium-dependent phospholipid-binding protein, is part of the annexin family and is expressed on cell surfaces, cytoplasm, and extracellular matrices. It interacts with S100A10 (p11) to form a heterotetrameric complex, which plays a critical role in fibrinolysis, endocytosis, exocytosis, and membrane-cytoskeletal dynamics. This complex also acts as a receptor for tissue plasminogen activator (tPA) and plasminogen, facilitating localized proteolytic activity.
ANXA2R is implicated in pathological conditions, particularly cancer and viral infections. Overexpression of ANXA2 in tumors correlates with metastasis, angiogenesis, and drug resistance in cancers like breast, pancreatic, and glioblastoma. Its role in promoting plasmin generation aids tumor invasion by degrading extracellular matrices. Additionally, ANXA2R serves as an entry receptor for pathogens, including SARS-CoV-2. where it may interact with viral spike proteins to facilitate cellular entry.
Recombinant ANXA2R, generated via genetic engineering, is utilized to study ligand-receptor interactions, screen therapeutic inhibitors, and elucidate molecular pathways in disease. Its application in research highlights its dual role as a regulator of physiological homeostasis and a contributor to pathology, making it a potential therapeutic target in oncology and infectious diseases.
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